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Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, pancreatic elastase 1 is not expressed in the pancreas. To date, elastase 1 expression has only been detected in skin keratinocytes. Clinical literature that describes human elastase 1 activity in the pancreas or fecal material is actually referring to chymotrypsin-like elastase family, member 3B.
Gene Name: | chymotrypsin-like elastase family, member 1 |
Family/Subfamily: | Protease , Serine S1 |
Synonyms: | CELA1, El1a, Elastase I, ELA1, Elastase 1, pancreatic, Elastase-1, Pancreatic elastase, Pancreatic elastase I, Porcine pancreatic elastase, Pancreatic elastase 1, Elastase |
Target Sequences: | NM_001971 NP_001962.3 Q9UNI1 |
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