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CDYL
chromodomain protein, Y-like
Acts as a RE1-silencing transcription factor (REST) corepressor that facilitates histone-lysine N-methyltransferase EHMT2 recruitment and H3K9 dimethylation at REST target genes for repression. Required for chromatin targeting and maximal enzymatic activity of polycomb repressive complex 2 (PRC2); acts as a positive regulator of PRC2 activity by bridging the pre-existing histone H3K27me3 and newly recruited PRC2 on neighboring nucleosomes. Has histone acetyltransferase activity, with a preference for histone H4.
| Gene Name: | chromodomain protein, Y-like |
| Synonyms: | CDYL, CDY-like, Chromodomain Y-like protein, CDY-like, autosomal, CDYL1, Chromodomain protein, Y-like, DKFZP586C1622 |
| Target Sequences: | NM_004824 NP_004815.3 Q9Y232 |
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