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CDKN3 / KAP
cyclin-dependent kinase inhibitor 3
CDKN3 encodes a dual specificity protein phosphatase which has been identified as a cyclin-dependent kinase inhibitor and has been shown to interact with, and dephosphorylate human CDK2 kinase. CDKN3 has also been shown to associate with human CDK3 and CDC2. The protein has been reported to remove phosphate from tyrosine residues in model substrates in vitro; however, a mutant protein that bears a lesion in the putative active site cysteine has been shown to lose catalytic activity. In HeLa cells, CDKN3 has been demonstrated to be expressed at the G1 to S transition and overexpression of wild-type CDKN3 has been shown to delay progression through the cell cycle. This gene has been reported to be deleted, mutated, or overexpressed in several kinds of cancers, including breast and prostate cancers.
| Gene Name: | cyclin-dependent kinase inhibitor 3 |
| Family/Subfamily: | Protein Phosphatase , Protein Phosphatase - Dual specificity other |
| Synonyms: | CDKN3, CIP2, Kinase-associated phosphatase, KAP, KAP1, CDI1, CDK-associated phosphatase, Kinase associated phosphatase |
| Target Sequences: | NM_005192 NP_005183.2 Q16667 |
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Products
Antibodies
(64)
Type
Primary
(64)
Target
CDKN3 / KAP
(64)
Reactivity
Human
(64)
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(20)
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(8)
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(6)
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(6)
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(19)
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(7)
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(60)
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(14)
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(21)
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(14)
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(2)
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rabbit
(46)
mouse
(18)
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(2)
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(32)
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(16)
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(2)
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monoclonal mc
(18)
polyclonal pc
(46)
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2.00E+11
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(1)
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(3)
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(7)
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(7)
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(7)
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(4)
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(33)
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(8)
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(7)
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(4)
1-80 aa, Internal
(1)
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(1)
Publications
No
(64)
CDKN3 / KAP Rabbit anti-Mouse Polyclonal (aa67-116) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$375
CDKN3 / KAP Rabbit anti-Mouse Polyclonal (aa67-116) (Biotin) Antibody
Rabbit, Mouse, Dog, Guinea pig, Rat, Pig, Horse, Gibbon, Human, Monkey
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
CDKN3 / KAP Mouse anti-Human Monoclonal (2E11) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$375
CDKN3 / KAP Mouse anti-Human Monoclonal (OTI5H1) Antibody
Human
Flo, IF, WB
Unconjugated
100 µl/$434
CDKN3 / KAP Mouse anti-Human Monoclonal (Carrier-free) (OTI5H1) Antibody
Human
Flo, IF, WB
Unconjugated, Carrier-free
100 µg/$511
CDKN3 / KAP Mouse anti-Human Monoclonal (Carrier-free) (2.00E+11) Antibody
Human
Flo, IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
CDKN3 / KAP Mouse anti-Human Monoclonal (OTI2H1) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
100 µl/$434
CDKN3 / KAP Mouse anti-Human Monoclonal (Carrier-free) (OTI2H1) Antibody
Human
Flo, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
CDKN3 / KAP Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$282; 200 µl/$350
CDKN3 / KAP Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
CDKN3 / KAP Mouse anti-Human Monoclonal (OTI1C7) Antibody
Human
Flo, IF, WB
Unconjugated
100 µl/$434
CDKN3 / KAP Mouse anti-Human Monoclonal (Carrier-free) (OTI1C7) Antibody
Human
Flo, IF, WB
Unconjugated, Carrier-free
100 µg/$511
CDKN3 / KAP Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
CDKN3 / KAP Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
CDKN3 / KAP Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
CDKN3 / KAP Rabbit anti-Human Polyclonal (C-Terminus) (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
CDKN3 / KAP Rabbit anti-Human Polyclonal (C-Terminus) (APC) Antibody
Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
CDKN3 / KAP Rabbit anti-Human Polyclonal (C-Terminus) (Azide-free) (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
CDKN3 / KAP Rabbit anti-Human Polyclonal (C-Terminus) (PE) Antibody
Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
CDKN3 / KAP Rabbit anti-Human Polyclonal (1-80 aa, Internal) Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
CDKN3 / KAP Mouse anti-Human Monoclonal (OTI4D8) Antibody
Human
IF, WB
Unconjugated
100 µl/$434
CDKN3 / KAP Mouse anti-Human Monoclonal (Carrier-free) (OTI4D8) Antibody
Human
IF, WB
Unconjugated, Carrier-free
100 µg/$511
CDKN3 / KAP Mouse anti-Human Monoclonal (OTI1H5) Antibody
Human
IF, WB
Unconjugated
100 µl/$434
CDKN3 / KAP Mouse anti-Human Monoclonal (Carrier-free) (OTI1H5) Antibody
Human
IF, WB
Unconjugated, Carrier-free
100 µg/$511
CDKN3 / KAP Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
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