CDKN2A

cyclin-dependent kinase inhibitor 2A

Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes. Binds to BCL6 and down-regulates BCL6-induced transcriptional repression. Binds to E2F1 and MYC and blocks their transcriptional activator activity but has no effect on MYC transcriptional repression. Binds to TOP1/TOPOI and stimulates its activity. This complex binds to rRNA gene promoters and may play a role in rRNA transcription and/or maturation. Interacts with NPM1/B23 and promotes its polyubiquitination and degradation, thus inhibiting rRNA processing. Interacts with COMMD1 and promotes its 'Lys63'-linked polyubiquitination. Interacts with UBE2I/UBC9 and enhances sumoylation of a number of its binding partners including MDM2 and E2F1. Binds to HUWE1 and represses its ubiquitin ligase activity. May play a role in controlling cell proliferation and apoptosis during mammary gland development. Isoform 6 may be involved in regulation of autophagy and caspase-independent cell death; the short-lived mitochondrial isoform is stabilized by C1QBP.

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Products

ELISA Kits (18)

Type

Custom (1)

Sandwich (15)

Sandwich CLIA (2)

Target

CDKN2A (18)

Reactivity

Human (6)

Mouse (5)

Rat (2)

Chicken (1)

Guinea pig (1)

Monkey (1)

Porcine (1)

Rabbit (1)

Format

12 x 8-Well Microstrips (3)

96-Well Microplate (2)

96-Well Strip Plate (13)

Publications

No (18)

Sample Type

Cell Lysates (2)

Plasma (9)

Serum (9)

Tissue Homogenates (5)

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Human CDKN2A (Sandwich ELISA) ELISA Kit - LS-F22610

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

0.63 - 40 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$651

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Rat CDKN2A (Sandwich ELISA) ELISA Kit - LS-F15224

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$669

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Mouse CDKN2A (Sandwich ELISA) ELISA Kit - LS-F23703

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Mouse

Range:

39.063 - 2500 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$586

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Human CDKN2A (Sandwich ELISA) ELISA Kit - LS-F26777

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

2.5 - 50 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$805

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Human CDKN2A (Sandwich ELISA) ELISA Kit - LS-F4067

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.625 - 40 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$764

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Human CDKN2A (CLIA) ELISA Kit - LS-F30316

Type:

Sandwich CLIA

Format:

12 x 8-Well Microstrips

Reactivity:

Human

Range:

125 - 8000 pg/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$656

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Mouse CDKN2A (Sandwich ELISA) ELISA Kit - LS-F35477

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

39.063 - 2500 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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Mouse CDKN2A (Sandwich ELISA) ELISA Kit - LS-F4068

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Tissue Homogenates

Price:

1 Plate/$782

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Mouse CDKN2A (Custom ELISA) ELISA Kit - LS-F15223

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Mouse

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$669

Select

Human CDKN2A (Sandwich ELISA) ELISA Kit - LS-F34582

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.625 - 40 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Mouse CDKN2A (CLIA) ELISA Kit - LS-F30489

Type:

Sandwich CLIA

Format:

12 x 8-Well Microstrips

Reactivity:

Mouse

Range:

15.625 - 1000 pg/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$656

Select

Guinea pig CDKN2A (Sandwich ELISA) ELISA Kit - LS-F42983

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Guinea pig

Range:

62.5 - 4000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$656

Select

Chicken CDKN2A (Sandwich ELISA) ELISA Kit - LS-F42984

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Chicken

Range:

31.25 - 2000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$656

Select

Monkey CDKN2A (Sandwich ELISA) ELISA Kit - LS-F42985

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Monkey

Range:

0.625 - 40 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$656

Select

Porcine CDKN2A (Sandwich ELISA) ELISA Kit - LS-F42986

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Porcine

Range:

0.625 - 40 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$656

Select

Rabbit CDKN2A (Sandwich ELISA) ELISA Kit - LS-F42987

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rabbit

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$656

Select

Human CDKN2A (Sandwich ELISA) ELISA Kit - LS-F54850

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.625 - 40 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$779

Select

Rat CDKN2A (Sandwich ELISA) ELISA Kit - LS-F38619

Type:

Sandwich

Format:

12 x 8-Well Microstrips

Reactivity:

Rat

Range:

31.25 - 2000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$586

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