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CDKN1B / p27 Kip1
cyclin-dependent kinase inhibitor 1B (p27, Kip1)
Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry.
| Gene Name: | cyclin-dependent kinase inhibitor 1B (p27, Kip1) |
| Synonyms: | CDKN1B, KIP1, MEN1B, P27 Kip1, p27KIP1, MEN4, CDKN4 |
| Target Sequences: | NM_004064 NP_004055.1 P46527 |
Publications (6)
1
Phosphorylation of p27Kip1 by Epstein-Barr virus protein kinase induces its degradation through SCFSkp2 ubiquitin ligase actions during viral lytic replication. Iwahori S, Murata T, Kudoh A, Sato Y, Nakayama S, Isomura H, Kanda T, Tsurumi T. The Journal of biological chemistry. 2009 284:18923-31. (WB)
[PubMed:19451650]
[PMC:PMC2707218]
2
Androgen Receptor Enhances p27 Degradation in Prostate Cancer Cells through Rapid and Selective TORC2 Activation. Fang Z, Zhang T, Dizeyi N, Chen S, Wang H, Swanson KD, Cai C, Balk SP, Yuan X. The Journal of biological chemistry. 2012 287:2090-8.
[PubMed:22139837]
[PMC:PMC3265888]
3
Dasatinib, a small molecule inhibitor of the Src kinase, reduces the growth and activates apoptosis in pre-neoplastic Barrett's esophagus cell lines: evidence for a noninvasive treatment of high-grade dysplasia. Landon J Inge, Aaron J Fowler, Kimberly M Paquette, Amanda L Richer, Nhan Tran, Ross M Bremner. The Journal of thoracic and cardiovascular surgery. 2013 February;145:531-8. [Full Text Article]
[PubMed:23142123]
Related Antibodies: LS-C335975.
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Products
ELISA Kits
(10)
Type
Cell-Based
(1)
Cell-Based Phosphorylation
(3)
Sandwich
(5)
Sandwich CLIA
(1)
Target
CDKN1B / p27 Kip1
(10)
Reactivity
Human
(7)
Mouse
(5)
Rat
(2)
Format
12 x 8-Well Microstrips
(1)
96-Well Microplate
(7)
96-Well Strip Plate
(2)
Publications
No
(10)
Sample Type
Adherent Cell Cultures
(4)
Cell Culture Supernatants
(1)
Cell Lysates
(1)
Plasma
(5)
Serum
(5)
Tissue Homogenates
(3)
Sandwich
96-Well Microplate
Human
0.041 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$610
Cell-Based
96-Well Microplate
Human
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$534
Cell-Based Phosphorylation
96-Well Microplate
Human
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$668
Cell-Based Phosphorylation
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$668
Cell-Based Phosphorylation
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$668
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
Sandwich
96-Well Microplate
Human
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$730
Sandwich
96-Well Microplate
Mouse
7.813 - 500 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
Sandwich CLIA
12 x 8-Well Microstrips
Mouse
3.125 - 200 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
Sandwich
96-Well Strip Plate
Mouse
7.813 - 500 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
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