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CDH18 / Ey-Cadherin is a type II classical cadherin from the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is expressed specifically in the central nervous system and is putatively involved in synaptic adhesion, axon outgrowth and guidance. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Gene Name: | cadherin 18, type 2 |
Family/Subfamily: | Cadherin , not assigned-Cadherin |
Synonyms: | CDH18, Cadherin 14-like, Cadherin-14, CDH14L, Cadherin 18, type 2, Cadherin-18, CDH14, EY-CADHERIN, Cadherin-like 24 |
Target Sequences: | NM_004934 NP_004925.1 Q13634 |
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