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CDH17 / Cadherin 17
cadherin 17, LI cadherin (liver-intestine)
CDH17 / Cadherin 17 is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. The encoded protein is cadherin-like, consisting of an extracellular region, containing 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. The protein may also play a role in the morphological organization of liver and intestine. Alternative splicing results in multiple transcript variants.
| Gene Name: | cadherin 17, LI cadherin (liver-intestine) |
| Family/Subfamily: | Cadherin , not assigned-Cadherin |
| Synonyms: | CDH17, Cadherin 16, Cadherin-16, HPT1, Human peptide transporter 1, LI cadherin, HPT-1, HPT-1 cadherin, BILL-cadherin, Cadherin, Cadherin-17, LI-cadherin, Liver-intestine cadherin |
| Target Sequences: | NM_004063 NP_004054.3 Q12864 |
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