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CDH10 / Cadherin 10 is a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is predominantly expressed in brain and is putatively involved in synaptic adhesions, axon outgrowth and guidance.
Gene Name: | cadherin 10, type 2 (T2-cadherin) |
Family/Subfamily: | Cadherin , not assigned-Cadherin |
Synonyms: | CDH10, Cadherin 10, T2-cadherin, Cadherin-10 |
Target Sequences: | NM_006727 NP_006718.2 Q9Y6N8 |
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