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Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates PPP1R12A.
Gene Name: | CDC42 binding protein kinase beta (DMPK-like) |
Family/Subfamily: | Protein Kinase , DMPK |
Synonyms: | CDC42BPB, CDC42BP-beta, CDC42-binding kinase beta, DMPK-like beta, MRCK beta, KIAA1124, MRCKB |
Target Sequences: | NM_006035 AAD37506.1 Q9Y5S2 |
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