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CDC23

cell division cycle 23

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

Gene Name: cell division cycle 23
Synonyms: CDC23, ANAPC8, APC8, Cell division cycle 23, CUT23, Cyclosome subunit 8
Target Sequences: NM_004661 NP_004652.2 Q9UJX2

Publications (3)

1
Accumulation of substrates of the anaphase-promoting complex (APC) during human cytomegalovirus infection is associated with the phosphorylation of Cdh1 and the dissociation and relocalization of APC subunits. Tran K, Mahr JA, Choi J, Teodoro JG, Green MR, Spector DH. Journal of virology. 2008 82:529-37. [PubMed:17942546] [PMC:PMC2224378]
2
Cdc20 is required for the post-anaphase, KEN-dependent degradation of centromere protein F. Gurden MD, Holland AJ, van Zon W, Tighe A, Vergnolle MA, Andres DA, Spielmann HP, Malumbres M, Wolthuis RM, Cleveland DW, Taylor SS. Journal of cell science. 2010 123:321-30. [PubMed:20053638] [PMC:PMC2816182]
3
Proteasome-dependent disruption of the E3 ubiquitin ligase anaphase-promoting complex by HCMV protein pUL21a. Fehr AR, Gualberto NC, Savaryn JP, Terhune SS, Yu D. PLoS pathogens. 2012 8:e1002789. [PubMed:22792066] [PMC:PMC3390409]

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).