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Infectious Disease
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Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
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Customer Service: (800) 227-6666 / (650) 697-3600
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CD8A / CD8 Alpha
CD8a molecule
The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain. Multiple transcript variants encoding different isoforms have been found for this gene.
| Gene Name: | CD8a molecule |
| Synonyms: | CD8A, CD8a molecule, CD8a antigen, OKT8 T-cell antigen, Leu2 T-lymphocyte antigen, T8 T-cell antigen, T cell co-receptor, p32, CD8, Leu2, T-cell antigen Leu2 |
| Target Sequences: | NM_001768 NP_001759.3 P01732 |
Publications (12)
1
Differential expression of the human CD8beta splice variants and regulation of the M-2 isoform by ubiquitination. Thakral D, Dobbins J, Devine L, Kavathas PB. Journal of immunology (Baltimore, Md. : 1950). 2008 180:7431-42.
[PubMed:18490743]
Related Antibodies: LS-C40806.
2
Human T cells express CD25 and Foxp3 upon activation and exhibit effector/memory phenotypes without any regulatory/suppressor function. Kmieciak M, Gowda M, Graham L, Godder K, Bear HD, Marincola FM, Manjili MH. Journal of translational medicine. 2009 7:89.
[PubMed:19849846]
[PMC:PMC2770477]
Related Antibodies: LS-C40806.
3
Immunization with a vaccine combining herpes simplex virus 2 (HSV-2) glycoprotein C (gC) and gD subunits improves the protection of dorsal root ganglia in mice and reduces the frequency of recurrent vaginal shedding of HSV-2 DNA in guinea pigs compared to. Awasthi S, Lubinski JM, Shaw CE, Barrett SM, Cai M, Wang F, Betts M, Kingsley S, Distefano DJ, Balliet JW, Flynn JA, Casimiro DR, Bryan JT, Friedman HM. Journal of virology. 2011 85:10472-86.
[PubMed:21813597]
[PMC:PMC3187515]
Related Antibodies: LS-C40805.
☰ Filters
Products
Proteins
(21)
Type
Over-Expression Lysate
(6)
Recombinant
(15)
Target
CD8A / CD8 Alpha
(21)
Application
Bind
(1)
ELISA
(1)
Func
(1)
SDS-PAGE
(1)
Publications
No
(21)
Tag
6His, N-terminus
(4)
6His-SUMO, N-terminus
(1)
Fc
(1)
GST
(1)
GST, N-terminus
(1)
His
(2)
His,C-terminus
(2)
His-GST
(1)
His-SUMO
(1)
Myc-DDK (Flag)
(6)
Species
Bovine
(1)
Cow
(1)
Human
(11)
Mouse
(3)
Rat
(2)
Source
293T Cells
(3)
CHO Cells
(1)
E. coli
(6)
HEK 293 Cells
(5)
Human Cells
(1)
Mammalian Cells
(1)
Wheat Germ Extract
(2)
Yeast
(2)
Purification
Purified
(6)
Low Endotoxin Level
Low endotoxin level
(4)
Biologically Active
Biologically active
(2)
CHO Cells
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
17.6 kDa
10 µg/$268; 50 µg/$349
E. coli
His-GST
56.8 kDa
10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284
Mammalian Cells
6His, N-terminus
100 µg/$1,009; 20 µg/$431; 1 mg/$3,451
HEK 293 Cells
His,C-terminus
Bind ELISA Func SDS-PAGE
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
The secreted recombinant mouse CD8a consists of 180 amino acids and has a calculated molecular mass of 20.3 kDa. As a result of glycosylation, the recombinant protein migrates as an approximately 35 kDa protein in SDS-PAGE under reducing conditions.
50 µg/$441; 1 mg/$2,479
E. coli
6His, N-terminus
19.8 kDa
10 µg/$265; 50 µg/$315; 100 µg/$365
Yeast
6His, N-terminus
100 µg/$446; 20 µg/$336; 1 mg/$1,460
293T Cells
Myc-DDK (Flag)
19.4 kDa
20 µg/$150
293T Cells
Myc-DDK (Flag)
25.67 kDa
20 µg/$150
293T Cells
Myc-DDK (Flag)
25.67 kDa
20 µg/$150
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
HEK 293 Cells
Myc-DDK (Flag)
25.67 kDa
100 µg/$494
HEK 293 Cells
Myc-DDK (Flag)
19.4 kDa
100 µg/$494
HEK 293 Cells
Myc-DDK (Flag)
25.67 kDa
100 µg/$494
HEK 293 Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
20.3 kDa
50 µg/$721
Wheat Germ Extract
GST
51.59 kDa
2 µg/$439
E. coli
His-SUMO
33.9 kD
1 mg/$1,679; 100 µg/$598; 20 µg/$405
E. coli
His
20.5 kDa
10 µg/$291; 50 µg/$502; 100 µg/$802; 200 µg/$1,002; 1 mg/$2,144; 500 µg/$1,668; 5 mg/$3,501; 2 mg/$2,334
E. coli
His
24.9 kDa
10 µg/$297; 50 µg/$540; 100 µg/$862; 200 µg/$1,061; 1 mg/$2,234; 500 µg/$1,749; 5 mg/$3,767; 2 mg/$2,425
E. coli
6His-SUMO, N-terminus
1 mg/$1,355; 100 µg/$420; 20 µg/$323
Yeast
6His, N-terminus
100 µg/$679; 20 µg/$429; 1 mg/$1,973
Human Cells
Fc
Less than 1.0 EU/µg protein (determined by LAL method).
45 kDa
100 µg/$843
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product results
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