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CD81

CD81 molecule

CD81 is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This protein appears to promote muscle cell fusion and support myotube maintenance. Also it may be involved in signal transduction. This gene is localized in the tumor-suppressor gene region and thus it is a candidate gene for malignancies. Two transcript variants encoding different isoforms have been found for this gene.

Gene Name: CD81 molecule
Family/Subfamily: Tetraspan , not assigned-Tetraspan
Synonyms: CD81, CD81 antigen, CD81 molecule, CVID6, S5.7, TAPA1, TAPA-1, Tetraspanin-28, TSPAN28, Tspan-28
Target Sequences: NM_004356 NP_004347.1 P60033

Publications (7)

1
Potentials and capabilities of the Extracellular Vesicle (EV) Array. Jørgensen MM, Bæk R, Varming K. Journal of Extracellular Vesicles. 2015 4:26048. (IHC; Human) [PubMed:25862471] [PMC:PMC4393420] Related Antibodies: LS-B7347.
2
Characterization of a Cell-Culturing System for the Study of Contact-Independent Extracellular Vesicle Communication. Revenfeld ALS, Søndergaard EKL, Stensballe A, Bæk R, Jørgensen MM, Varming K. Journal of circulating biomarkers. 2016 February;5:3. (Human) [Full Text Article] [PubMed:28936251] [PMC:PMC5548315] Related Antibodies: LS-B7347.
3
Induction of a Regulatory Phenotype in CD3+ CD4+ HLA-DR+ T Cells after Allogeneic Mixed Lymphocyte Culture; Indications of Both Contact-Dependent and -Independent Activation. Revenfeld ALS, Bæk R, Jørgensen MM, Varming K, Stensballe A. International journal of molecular sciences. 2017 July;18:pii: E1603. (Human) [Full Text Article] [PubMed:28737722] [PMC:PMC5536089] Related Antibodies: LS-B7347.
4
An miRNA fingerprint using neural-enriched extracellular vesicles from blood plasma: towards a biomarker for amyotrophic lateral sclerosis/motor neuron disease. Sandra Anne Banack, Rachael Anne Dunlop, Paul Alan Cox. Open biology. 2020 Jun;10:200116. [Full Text Article] [PubMed:32574550] [PMC:PMC7333885]
5
Enrichment of Neurodegenerative Microglia Signature in Brain-Derived Extracellular Vesicles Isolated from Alzheimer's Disease Mouse Models. Satoshi Muraoka, Mark P Jedrychowski, Naotoshi Iwahara, Mohammad Abdullah, Kristen D Onos, Kelly J Keezer, Jianqiao Hu, Seiko Ikezu, Gareth R Howell, Steven P Gygi, Tsuneya Ikezu. Journal of proteome research. 2021 Mar;20:1733-1743. [Full Text Article] [PubMed:33534581] [PMC:PMC7944570] Related Antibodies: LS-C350457.
6
Exploring the molecular content of CHO exosomes during bioprocessing. Christoph Keysberg , Oliver Hertel , Louise Schelletter , Tobias Busche, Chiara Sochart, Jörn Kalinowski, Raimund Hoffrogge , Kerstin Otte, Thomas Noll. Applied microbiology and biotechnology. 2021 May;;105:3673-3689. [Full Text Article] [PubMed:33937930] [PMC:PMC8102462] Related Antibodies: LS-C108453.
7
Extracellular Vesicle (EV) Array: microarray capturing of exosomes and other extracellular vesicles for multiplexed phenotyping. Jorgensen M1, Baek R, Pedersen S, Sondergaard EK, Kristensen SR, Varming K. Journal of Extracellular Vesicles. 2013 Jun 18;2: [Full Text Article] [PubMed:24009888] [PMC:PMC3760630] Related Antibodies: LS-B7347, LS-C35761.
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☰ Filters
Products
Proteins (11)
Over-Expression Lysate (2)
Recombinant (8)
CD81 (11)
SDS-PAGE (1)
No (11)
Fc, N-terminus (1)
GST, N-terminus (1)
His (1)
His, N-Terminal (1)
His-SUMO (1)
Myc-DDK (Flag) (3)
Human (9)
Rat (1)
293T Cells (1)
E. coli (2)
HEK 293 Cells (4)
Human (1)
Wheat Germ Extract (1)
Yeast (1)
Purified (2)
Low endotoxin level (4)
CD81 Protein - Recombinant Target Of The Antiproliferative Antibody 1 By SDS-PAGE
Select
E. coli
His, N-Terminal
13.4 kDa
10 µg/$290; 50 µg/$500; 100 µg/$797; 200 µg/$997; 1 mg/$2,139; 500 µg/$1,662; 5 mg/$3,487; 2 mg/$2,329
CD81 Protein
Select
HEK 293 Cells
None
SDS-PAGE
Less than 1.0 EU/µg protein (determined by LAL method).
The recombinant human CD81 comprises 91 amino acids and has a predicted molecular mass of 9.9 kDa. The apparent molecular mass of the monomer is approximately 10 kDa in SDS-PAGE under reducing conditions.
100 µg/$441
CD81 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
Select
Wheat Germ Extract
GST, N-terminus
2 µg/$439
CD81 Protein - Purified recombinant protein CD81 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
25.6 kDa
20 µg/$1,107
CD81 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
25.6 kDa
20 µg/$150
CD81 Protein
Select
E. coli
His-SUMO
25.8 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
CD81 Protein
Select
Yeast
His
11.8 kD
100 µg/$446; 20 µg/$336; 1 mg/$1,460
CD81 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
25.6 kDa
100 µg/$494
CD81 Protein - Recombinant Human CD81 (N-FC)
Select
Human
Fc, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
36.1 kDa
10 µg/$308; 50 µg/$502
Select
HEK 293 Cells
None
Less than 1.0 EU/µg protein (determined by LAL method).
9.7 kDa
100 µg/$843
Select
None
Less than 1.0 EU/µg protein (determined by LAL method).
100 µg/$480; 1 mg/$2,333
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).