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CD68

CD68 molecule

CD68 is a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface. It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins. The protein is also a member of the scavenger receptor family. Scavenger receptors typically function to clear cellular debris, promote phagocytosis, and mediate the recruitment and activation of macrophages. Alternative splicing results in multiple transcripts encoding different isoforms.

Gene Name: CD68 molecule
Synonyms: CD68, CD68 antigen, gp110, SCARD1, CD68 molecule, LAMP4, Macrophage antigen CD68, Macrosialin
Target Sequences: NM_001251 NP_001242.2 P34810

Publications (5)

1
Aneurysm Severity is Increased by Combined Mmp-7 Deletion and N-cadherin Mimetic (EC4-Fc) Over-Expression. Lyon CA, Williams H, Bianco R, Simmonds SJ, Brown BA, Wadey KS, Smith FCT, Johnson JL, George SJ. Scientific reports. 2017 December;7:17342. (Mouse) [Full Text Article] [PubMed:29229950] [PMC:PMC5725451]
2
CD1b-restricted GEM T cell responses are modulated by Mycobacterium tuberculosis mycolic acid meromycolate chains. Chancellor A, Tocheva AS, Cave-Ayland C, Tezera L, White A, Al Dulayymi JR, Bridgeman JS, Tews I, Wilson S, Lissin NM, Tebruegge M,, Marshall B,, Sharpe S, Elliott T, Skylaris CK, Essex JW, Baird MS, Gadola S, Elkington P,, Mansour S. Proceedings of the National Academy of Sciences of the United States of America. 2017 December;114:E10956-E10964. [Full Text Article] [PubMed:29158404] [PMC:PMC5754766] Related Antibodies: LS-C188452.
3
Reduced patency in left-sided arteriovenous grafts in a porcine model. Shirley Liu, Tun Wang, Juan Wang, Toshihiko Isaji, Shun Ono, Arash Fereydooni, Ryosuke Taniguchi, Yutaka Matsubara, Laura E Niklason, Alan Dardik. Journal of vascular surgery. 2020 July;72:305-317.e6. [Full Text Article] [PubMed:31699515] [PMC:PMC7196525] Related Antibodies: LS-C187543.
4
Adenovirus 14p1 Immunopathogenesis during Lung Infection in the Syrian Hamster. Jay R Radke, Hunter J Covert, Fredrick Bauer, Vijayalakshmi Ananthanarayanan, James L Cook. Viruses. 2020 May;12: [Full Text Article] [PubMed:32486177] [PMC:PMC7354616]
5
An ex vivo physiologic and hyperplastic vessel culture model to study intra-arterial stent therapies. Juan Wang, Mehmet H Kural, Jonathan Wu, Katherine L Leiby, Vinayak Mishra, Taras Lysyy, Guangxin Li, Jiesi Luo, Allison Greaney, George Tellides, Yibing Qyang, Nan Huang, Laura E Niklason. Biomaterials. 2021 August;275:120911. [Full Text Article] [PubMed:34087584] [PMC:PMC9195126] Related Antibodies: LS-C187543.
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ELISA Kits (8)
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CD68 (8)
Human (3)
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Plasma (7)
Serum (7)
Tissue Homogenates (5)
CD68 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
CD68 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
CD68 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.78 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
CD68 ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.781 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
CD68 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
CD68 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
0.781 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
CD68 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$822
CD68 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$798
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).