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CD66a / CEACAM1

carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)

CD66a / CEACAM1 encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of all variants has not been defined.

Gene Name: carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
Family/Subfamily: CEA , not assigned-CEA
Synonyms: CEACAM1, Antigen CD66, BGP1, Biliary glycoprotein 1, CD66a, BGP-1, BGP, BGPI, CD66a antigen
Target Sequences: NM_001712 NP_001703.2 P13688

Publications (5)

1
Invasive Ductular Reaction Operates Hepatobiliary Junctions upon Hepatocellular Injury in Rodents and Humans. Clerbaux LA, Manco R, Van Hul N, Bouzin C, Sciarra A, Sempoux C, Theise ND, Leclercq IA. The American journal of pathology. 2019 August;189:1569-1581. [Full Text Article] [PubMed:31108103] Related Antibodies: LS-C106710.
2
Compensatory hepatic adaptation accompanies permanent absence of intrahepatic biliary network due to YAP1 loss in liver progenitors10<sup> Division of Hematology/Oncology, Department of Medicine, University of Pittsburgh School of Medicine and UPMC, Pittsburgh, PA, USA12<sup> Center for Biologic Imaging, University of Pittsburgh, Pittsburgh, PA, USA; Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA14<sup> Division of Gastroenterology, Hepatology, and N. Laura M Molina, Junjie Zhu, Qin Li, Tirthadipa Pradhan-Sundd, Yekaterina Krutsenko, Khaled Sayed, Nathaniel Jenkins, Ravi Vats, Bharat Bhushan, Sungjin Ko, Shikai Hu, Minakshi Poddar, Sucha Singh, Junyan Tao, Prithu Sundd, Aatur Singhi, Simon Watkins, Xiaochao Ma, Panayiotis V Benos, Andrew Feranchak, George Michalopoulos, Kari Nejak-Bowen, Alan Watson, Aaron Bell, Satdarshan P Monga. Cell reports. 2021 Jul;36:109310. [Full Text Article] [PubMed:34233187] [PMC:PMC8280534] Related Antibodies: LS-C106710.
3
Apical expression of human full-length hCEACAM1-4L protein renders the Madin Darby Canine Kidney cells responsive to lipopolysaccharide leading to TLR4-dependent Erk1/2 and p38 MAPK signalling. Li[Character e9]vin-Le Moal V, Beau I, Rougeaux C, Kansau I, Fabrega S, Brice C, Korotkova N, Moseley SL, Servin AL. Cellular microbiology. 2011 May;13:764-85. [Full Text Article] [PubMed:21352462] Related Antibodies: LS-C6024.
4
Embryonic ductal plate cells give rise to cholangiocytes, periportal hepatocytes, and adult liver progenitor cells. Carpentier R, Su[Character f1]er RE, van Hul N, Kopp JL, Beaudry JB, Cordi S, Antoniou A, Raynaud P, Lepreux S, Jacquemin P, Leclercq IA, Sander M, Lemaigre FP. Gastroenterology. 2011 Oct;141:1432-8, 1438.e1-4. [Full Text Article] [PubMed:21708104] [PMC:PMC3494970] Related Antibodies: LS-C106710.
5
Liver progenitor cells yield functional hepatocytes in response to chronic liver injury in mice. Espa[Character f1]ol-Su[Character f1]er R, Carpentier R, Van Hul N, Legry V, Achouri Y, Cordi S, Jacquemin P, Lemaigre F, Leclercq IA. Gastroenterology. 2012 Dec;143:1564-1575.e7. [Full Text Article] [PubMed:22922013] Related Antibodies: LS-C106710.
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Products
Proteins (23)
Native (1)
Over-Expression Lysate (4)
Recombinant (18)
CD66a / CEACAM1 (23)
No (23)
10His-SUMO, N-terminus + Myc, C-terminus (1)
6His, C-terminus (1)
GST (2)
GST, N-terminus (1)
His (4)
His, N-terminus + His, C-terminus (2)
His,C-terminus (3)
Myc-DDK (Flag) (7)
Human (14)
Mouse (3)
Rat (3)
Sheep (1)
293T Cells (2)
E. coli (7)
HEK 293 Cells (7)
Human Cells (2)
Mammalian Cells (1)
Sheep (1)
Wheat Germ Extract (3)
Purified (6)
Low endotoxin level (5)
Select
HEK 293 Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
45 kDa
100 µg/$721
CD66a / CEACAM1 Protein - 12.5% SDS-PAGE of human CEACAM1 stained with Coomassie Blue
Select
Wheat Germ Extract
GST
77 kDa
10 µg/$479; 25 µg/$670
CD66a / CEACAM1 Protein - Recombinant Carcinoembryonic Antigen Related Cell Adhesion Molecule 1 By SDS-PAGE
Select
E. coli
His
33.0 kDa
10 µg/$262; 50 µg/$339; 100 µg/$512; 200 µg/$642; 1 mg/$1,623; 500 µg/$1,214; 5 mg/$2,562; 2 mg/$1,796
CD66a / CEACAM1 Protein - Recombinant Carcinoembryonic Antigen Related Cell Adhesion Molecule 1 By SDS-PAGE
Select
E. coli
His
13.8 kDa
10 µg/$267; 50 µg/$352; 100 µg/$562; 200 µg/$702; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900
Select
Sheep
None
10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$3,201
CD66a / CEACAM1 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
Select
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
Select
Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
44.9 kDa
100 µg/$721
CD66a / CEACAM1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
47.4 kDa
20 µg/$150
CD66a / CEACAM1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
50.8 kDa
20 µg/$150
Select
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
44.33kD
10 µg/$269; 50 µg/$372; 500 µg/$1,585; 1 mg/$2,157
CD66a / CEACAM1 Protein - Purified recombinant protein CEACAM1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
46.7 kDa
20 µg/$1,107
CD66a / CEACAM1 Protein - Purified recombinant protein CEACAM1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
50.8 kDa
20 µg/$1,107
CD66a / CEACAM1 Protein - Purified recombinant protein CEACAM1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
47.4 kDa
20 µg/$1,107
CD66a / CEACAM1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
50.8 kDa
100 µg/$494
CD66a / CEACAM1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
47.4 kDa
100 µg/$494
CD66a / CEACAM1 Protein - Recombinant Mouse Ceacam1/BGP-1 protein (His Tag)
Select
E. coli
His, N-terminus + His, C-terminus
43.9kDa
20 µg/$270; 100 µg/$390
CD66a / CEACAM1 Protein - Recombinant Rat Ceacam1/BGP-1 protein (His Tag)
Select
E. coli
His, N-terminus + His, C-terminus
45.13kDa
20 µg/$270; 100 µg/$390
Select
HEK 293 Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
45 kDa
100 µg/$721
CD66a / CEACAM1 Protein - 12.5% SDS-PAGE of human CEACAM1 stained with Coomassie Blue
Select
Wheat Germ Extract
GST
76.9 kDa
10 µg/$479; 25 µg/$670
CD66a / CEACAM1 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
10His-SUMO, N-terminus + Myc, C-terminus
1 mg/$1,355; 100 µg/$420; 20 µg/$323
CD66a / CEACAM1 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
None
1 mg/$1,443; 100 µg/$503; 20 µg/$406
Select
Mammalian Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
44.33 kDa
10 µg/$269; 50 µg/$368
CD66a / CEACAM1 Protein - Recombinant Carcinoembryonic Antigen Related Cell Adhesion Molecule 1 By SDS-PAGE
Select
E. coli
His
14.0 kDa
10 µg/$259; 50 µg/$331; 100 µg/$482; 200 µg/$602; 1 mg/$1,553; 500 µg/$1,156; 5 mg/$2,481; 2 mg/$1,723
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).