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CD66a / CEACAM1

carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)

CD66a / CEACAM1 encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of all variants has not been defined.

Gene Name: carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
Family/Subfamily: CEA , not assigned-CEA
Synonyms: CEACAM1, Antigen CD66, BGP1, Biliary glycoprotein 1, CD66a, BGP-1, BGP, BGPI, CD66a antigen
Target Sequences: NM_001712 NP_001703.2 P13688

Publications (5)

1
Invasive Ductular Reaction Operates Hepatobiliary Junctions upon Hepatocellular Injury in Rodents and Humans. Clerbaux LA, Manco R, Van Hul N, Bouzin C, Sciarra A, Sempoux C, Theise ND, Leclercq IA. The American journal of pathology. 2019 August;189:1569-1581. [Full Text Article] [PubMed:31108103] Related Antibodies: LS-C106710.
2
Compensatory hepatic adaptation accompanies permanent absence of intrahepatic biliary network due to YAP1 loss in liver progenitors10<sup> Division of Hematology/Oncology, Department of Medicine, University of Pittsburgh School of Medicine and UPMC, Pittsburgh, PA, USA12<sup> Center for Biologic Imaging, University of Pittsburgh, Pittsburgh, PA, USA; Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA14<sup> Division of Gastroenterology, Hepatology, and N. Laura M Molina, Junjie Zhu, Qin Li, Tirthadipa Pradhan-Sundd, Yekaterina Krutsenko, Khaled Sayed, Nathaniel Jenkins, Ravi Vats, Bharat Bhushan, Sungjin Ko, Shikai Hu, Minakshi Poddar, Sucha Singh, Junyan Tao, Prithu Sundd, Aatur Singhi, Simon Watkins, Xiaochao Ma, Panayiotis V Benos, Andrew Feranchak, George Michalopoulos, Kari Nejak-Bowen, Alan Watson, Aaron Bell, Satdarshan P Monga. Cell reports. 2021 Jul;36:109310. [Full Text Article] [PubMed:34233187] [PMC:PMC8280534] Related Antibodies: LS-C106710.
3
Apical expression of human full-length hCEACAM1-4L protein renders the Madin Darby Canine Kidney cells responsive to lipopolysaccharide leading to TLR4-dependent Erk1/2 and p38 MAPK signalling. Li[Character e9]vin-Le Moal V, Beau I, Rougeaux C, Kansau I, Fabrega S, Brice C, Korotkova N, Moseley SL, Servin AL. Cellular microbiology. 2011 May;13:764-85. [Full Text Article] [PubMed:21352462] Related Antibodies: LS-C6024.
4
Embryonic ductal plate cells give rise to cholangiocytes, periportal hepatocytes, and adult liver progenitor cells. Carpentier R, Su[Character f1]er RE, van Hul N, Kopp JL, Beaudry JB, Cordi S, Antoniou A, Raynaud P, Lepreux S, Jacquemin P, Leclercq IA, Sander M, Lemaigre FP. Gastroenterology. 2011 Oct;141:1432-8, 1438.e1-4. [Full Text Article] [PubMed:21708104] [PMC:PMC3494970] Related Antibodies: LS-C106710.
5
Liver progenitor cells yield functional hepatocytes in response to chronic liver injury in mice. Espa[Character f1]ol-Su[Character f1]er R, Carpentier R, Van Hul N, Legry V, Achouri Y, Cordi S, Jacquemin P, Lemaigre F, Leclercq IA. Gastroenterology. 2012 Dec;143:1564-1575.e7. [Full Text Article] [PubMed:22922013] Related Antibodies: LS-C106710.
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ELISA Kits (10)
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CD66a / CEACAM1 (10)
Human (7)
Mouse (2)
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CD66a / CEACAM1 ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
CD66a / CEACAM1 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
78.13 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$748
CD66a / CEACAM1 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$585
CD66a / CEACAM1 ELISA Kit
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Sandwich
96-Well Microplate
Human
20.58 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$760
CD66a / CEACAM1 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$730
CD66a / CEACAM1 ELISA Kit
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Sandwich
96-Well Microplate
Human
312 - 20000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$699
CD66a / CEACAM1 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
312 - 20000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$624
CD66a / CEACAM1 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
CD66a / CEACAM1 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.78 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$897
CD66a / CEACAM1 ELISA Kit
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Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$669
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).