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CD44

CD44 molecule (Indian blood group)

Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events.

Gene Name: CD44 molecule (Indian blood group)
Synonyms: CD44, CDW44, CD44 antigen, Cell surface glycoprotein CD44, CSPG8, ECMR-III, Epican, HUTCH-I, LHR, MDU2, MC56, MIC4, Hermes antigen, Hyaluronate receptor, Phagocytic glycoprotein 1, PGP-1, PGP-I, Pgp1, Phagocytic glycoprotein I, MDU3, CD44R, HCELL, Heparan sulfate proteoglycan
Target Sequences: NM_000610 NP_000601.3 P16070

Publications (14)

1
Rare steroid receptor-negative basal-like tumorigenic cells in luminal subtype human breast cancer xenografts. Horwitz KB, Dye WW, Harrell JC, Kabos P, Sartorius CA. Proceedings of the National Academy of Sciences of the United States of America. 2008 105:5774-9. (IHC) [PubMed:18391223] [PMC:PMC2311360]
2
Peritoneal tumor carcinomatosis: pharmacological targeting with hyaluronan-based bioconjugates overcomes therapeutic indications of current drugs. Montagner IM, Merlo A, Zuccolotto G, Renier D, Campisi M, Pasut G, Zanovello P, Rosato A. PloS one. 2014 9:e112240. (Flo; Human) [Full Text Article] [PubMed:25383653] [PMC:PMC4226476]
3
Drug conjugation to hyaluronan widens therapeutic indications for ovarian cancer. Montagner IM, Merlo A, Carpanese D, Zuccolotto G, Renier D, Campisi M, Pasut G, Zanovello P, Rosato A. Oncoscience. 2015 2:373-81. (Flo; Human) [PubMed:26097871] [PMC:PMC4468323]
4
Osteopontin inhibits HIF-2a mRNA expression in osteoarthritic chondrocytes. Cheng C, Zhang FJ, Tian J, Tu M, Xiong YL, Luo W, Li YS, Song BB, Gao SG, Lei GH. Experimental and therapeutic medicine. 2015 9:2415-2419. (Block; Human) [Full Text Article] [PubMed:26136997] [PMC:PMC4473661]
5
Auramine O, an incense smoke ingredient, promotes lung cancer malignancy. Tung JC, Huang WC, Yang JC, Chen GY, Fan CC, Chien YC, Lin PS, Candice Lung SC, Chang WC. Environmental toxicology. 2017 32:2379-2391. (IP; Human) [Full Text Article] [PubMed:28722353] [PMC:PMC5655719] Related Antibodies: LS-C44932.
6
Senescent Atrophic Epidermis Retains Lrig1+ Stem Cells and Loses Wnt Signaling, a Phenotype Shared with CD44KO Mice. Barnes L, Saurat JH, Kaya G. PloS one. 2017 January;12:e0169452. (Mouse) [Full Text Article] [PubMed:28099467] [PMC:PMC5242443] Related Antibodies: LS-C44149.
7
Adaptive Regulation of Osteopontin Production by Dendritic Cells Through the Bidirectional Interaction With Mesenchymal Stromal Cells. Scutera S, Salvi V, Lorenzi L, Piersigilli G, Lonardi S, Alotto D, Casarin S, Castagnoli C, Dander E, D'Amico G, Sozzani S, Musso T. Frontiers in immunology. 2018 June;9:1207. (Human) [Full Text Article] [PubMed:29910810] [PMC:PMC5992779]
8
Anti-inflammatory protein TSG-6 secreted by activated MSCs attenuates zymosan-induced mouse peritonitis by decreasing TLR2/NF-?B signaling in resident macrophages. Hosoon Choi, Ryang Hwa Lee, Nikolay Bazhanov, Joo Youn Oh, Darwin J Prockop. Blood. 2011 July;118:330-8. [Full Text Article] [PubMed:21551236] [PMC:PMC3138686] Related Antibodies: LS-C34583.
9
Immunohistochemistry in Investigative and Toxicologic Pathology. Kyathanahalli S Janardhan, Heather Jensen, Natasha P Clayton, Ronald A Herbert. Toxicologic pathology. 2018 July;46:488-510. [Full Text Article] [PubMed:29966501] [PMC:PMC6033701] Related Antibodies: LS-B5508.
10
A novel kartogenin-platelet-rich plasma gel enhances chondrogenesis of bone marrow mesenchymal stem cells in vitro and promotes wounded meniscus healing in vivo. Feng Liu, Hongyao Xu, He Huang. Stem cell research & therapy. 2019 July;10:201. [Full Text Article] [PubMed:31287023] [PMC:PMC6615105] Related Antibodies: LS-C13434.
11
CD24-targeted fluorescence imaging in patient-derived xenograft models of high-grade serous ovarian carcinoma. Katrin Kleinmanns, Katharina Bischof, Shamundeeswari Anandan, Mihaela Popa, Lars A Akslen, Vibeke Fosse, Ida Tveit Karlsen, Bjørn T Gjertsen, Line Bjørge, Emmet McCormack. EBioMedicine. 2020 Jun;56:102782. [Full Text Article] [PubMed:32454401] [PMC:PMC7248428] Related Antibodies: LS-C46494.
12
New monoclonal antibodies that recognize an unglycosylated, conserved, extracellular region of CD44 in vitro and in vivo, and can block tumorigenesis. Daniel F Lusche, Deborah J Wessels, Ryan J Reis, Cristopher C Forrest, Alexis R Thumann, David R Soll. PloS one. 2021 Apr;16:e0250175. [Full Text Article] [PubMed:33891595] [PMC:PMC8064539]
13
Breast Cancer Cell-Derived Soluble CD44 Promotes Tumor Progression by Triggering Macrophage IL1ß Production. Jeong-Hoon Jang, Do-Hee Kim, Jae Min Lim, Joon Won Lee, Su Jin Jeong, Kwang Pyo Kim, Young-Joon Surh. Cancer research. 2020 March;80:1342-1356. [Full Text Article] [PubMed:31969374]
14
Osteopontin inhibits osteoarthritis progression via the OPN/CD44/PI3K signal axis. Qing Liu, Hao Zeng, Yuhao Yuan, Zhiwei Wang, Ziyi Wu, Wei Luo. Genes & diseases. 2022 January;9:128-139. [Full Text Article] [PubMed:35005113] [PMC:PMC8720673]
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Products
Proteins (19)
Over-Expression Cell Culture Supernatant (1)
Over-Expression Lysate (7)
Recombinant (11)
CD44 (19)
No (18)
Yes (1)
6His, C-terminus (2)
6His, N-terminus (3)
6His-SUMO, N-terminus (2)
Fc, C-terminus (2)
GST (2)
Myc-DDK (Flag) (8)
Human (16)
293T Cells (3)
E. coli (3)
HEK 293 Cells (7)
Human Cells (2)
Mammalian Cells (2)
Wheat Germ Extract (2)
Purified (4)
Low endotoxin level (4)
CD44 Protein
Select
E. coli
6His-SUMO, N-terminus
80.1 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
Select
E. coli
6His, N-terminus
24 kDa
10 µg/$265; 50 µg/$315; 100 µg/$365
CD44 Protein - 12.5% SDS-PAGE of human CD44 stained with Coomassie Blue
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Wheat Germ Extract
GST
65.8 kDa
10 µg/$479; 25 µg/$670
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Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
23.1kD
10 µg/$269; 50 µg/$372; 500 µg/$1,585; 1 mg/$2,157
Select
Human Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
49.2kD
10 µg/$281; 50 µg/$395; 500 µg/$1,585; 1 mg/$2,157
CD44 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
81.54 kDa
100 µg/$710
Select
293T Cells
Myc-DDK (Flag)
76.63 kDa
20 µg/$150
CD44 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
81.54 kDa
20 µg/$215
CD44 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
39.42 kDa
20 µg/$150
CD44 Protein - Purified recombinant protein CD44 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
79.2 kDa
20 µg/$1,107
CD44 Protein - Purified recombinant protein CD44 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
74.2 kDa
20 µg/$1,107
CD44 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
76.63 kDa
100 µg/$494
CD44 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
39.42 kDa
100 µg/$494
Select
Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
23.1 kDa
10 µg/$269; 50 µg/$368
CD44 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
6His-SUMO, N-terminus
38.1 kDa
1 mg/$1,355; 100 µg/$420; 20 µg/$323
CD44 Protein - 12.5% SDS-PAGE of human CD44 stained with Coomassie Blue
Select
Wheat Germ Extract
GST
102.63 kDa
2 µg/$439
Select
HEK 293 Cells
6His, N-terminus
25 kDa
100 µg/$298
Select
HEK 293 Cells
6His, N-terminus
25 kDa
200 µl/$283
Select
Mammalian Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
49.2 kDa
10 µg/$281; 50 µg/$389
Viewing 1-19 of 19 product results


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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).