CD40

CD40 molecule, TNF receptor superfamily member 5

CD40 is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

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Products

Proteins (28)

Type

Over-Expression Lysate (5)

Recombinant (23)

Target

CD40 (28)

Publications

No (28)

Tag

6His, C-terminus (2)

Fc (1)

Fc, C-terminus (5)

Fc-6His, C-terminus (1)

GST (3)

His (2)

His,C-terminus (4)

His-T7 (2)

Human IgG1 Fc (2)

mFc, C-terminus (1)

Myc-DDK (Flag) (5)

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Species

Crab-eating macaque (2)

Human (16)

Mouse (5)

Rat (3)

Source

293T Cells (3)

CHO Cells (1)

E. coli (4)

HEK 293 Cells (4)

Human Cells (5)

Mammalian Cells (8)

Wheat Germ Extract (3)

Purification

Purified (7)

Low Endotoxin Level

Low endotoxin level (16)

Biologically Active

Biologically active (2)

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Mouse CD40 Protein (Recombinant 6His, C-terminus) (Leu20-Arg193) - LS-G40367

Source:

Human Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

20.2kD

Price:

10 µg/$281; 50 µg/$395; 500 µg/$1,585; 1 mg/$2,157

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Human CD40 Protein (Recombinant His-T7) (aa26-187) - LS-G13564

Source:

E. coli

Tag:

His-T7

Molecular Weight:

21.5 kDa

Price:

50 µg/$440; 10 µg/$281; 200 µg/$877; 100 µg/$702; 1 mg/$1,983; 500 µg/$1,523; 5 mg/$3,067; 2 mg/$2,170

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Human CD40 Protein (Recombinant His) - LS-G2835

Source:

E. coli

Tag:

His

Price:

50 µg/$361; 250 µg/$739; 10 µg/$261

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Human CD40 Protein (Recombinant 6His, C-terminus) (Glu21-Arg193) - LS-G38848

Source:

Human Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

20.2kD

Price:

10 µg/$248; 50 µg/$313; 500 µg/$743; 1 mg/$1,048

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Mouse CD40 Protein (Recombinant Fc, C-terminus) (Leu20-Arg193) - LS-G40160

Source:

Human Cells

Tag:

Fc, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

46.5kD

Price:

10 µg/$266; 50 µg/$343; 500 µg/$1,377; 1 mg/$1,765

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Human CD40 Protein (Recombinant Fc-6His, C-terminus) (Glu21-Arg193) - LS-G39450

Source:

Human Cells

Tag:

Fc-6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

46.3kD

Price:

10 µg/$281; 50 µg/$395; 500 µg/$1,585; 1 mg/$2,157

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Human CD40 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G88096

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

30.62 kDa

Price:

20 µg/$150

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Human CD40 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G88097

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

20.1 kDa

Price:

20 µg/$150

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Human CD40 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G88098

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

20.1 kDa

Price:

20 µg/$150

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Rat CD40 Protein (Recombinant Fc) (Met1-Arg193) - LS-G98333

Source:

Human Cells

Tag:

Fc

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

46.2 kDa

Price:

100 µg/$721

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CD40 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99383

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

30.62 kDa

Price:

100 µg/$494

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CD40 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G105912

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

20.1 kDa

Price:

100 µg/$494

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Human CD40 Protein (Recombinant Fc, C-terminus) - LS-G136763

Source:

Mammalian Cells

Tag:

Fc, C-terminus

Biological Activity:

Biologically active

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

46.3 kDa

Price:

50 µg/$453; 10 µg/$303; 1 mg/$2,837; 500 µg/$1,987

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Human CD40 Protein (Recombinant His,C-terminus) (Glu21-Arg193) - LS-G138697

Source:

Mammalian Cells

Tag:

His,C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

20.2 kDa

Price:

10 µg/$248; 50 µg/$311

Select

Human CD40 Protein (Recombinant Fc, C-terminus) (Glu21-Arg193) - LS-G139051

Source:

Mammalian Cells

Tag:

Fc, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

46.3 kDa

Price:

10 µg/$281; 50 µg/$389

Select

Rat CD40 Protein (Recombinant His,C-terminus) (Met1-Arg193) - LS-G138215

Source:

HEK 293 Cells

Tag:

His,C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

20.6 kDa

Price:

100 µg/$721

Select

Mouse CD40 Protein (Recombinant Fc, C-terminus) (Leu20-Arg193) - LS-G138866

Source:

Mammalian Cells

Tag:

Fc, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

46.5 kDa

Price:

10 µg/$266; 50 µg/$339

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Human CD40 Protein (Recombinant mFc, C-terminus) (Glu21-Arg193) - LS-G138839

Source:

Mammalian Cells

Tag:

mFc, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

45.7 kDa

Price:

10 µg/$262; 50 µg/$339

Select

Mouse CD40 Protein (Recombinant His,C-terminus) (Leu20-Arg193) - LS-G139369

Source:

Mammalian Cells

Tag:

His,C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

20.2 kDa

Price:

10 µg/$281; 50 µg/$389

Select

Crab-eating macaque CD40 Protein (Recombinant His,C-terminus) (Glu21-Arg193) - LS-G139408

Source:

Mammalian Cells

Tag:

His,C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

20.2 kDa

Price:

10 µg/$281; 50 µg/$389

Select

Human CD40 Protein (Recombinant Human IgG1 Fc) (aa21-193) - LS-G3924

Source:

HEK 293 Cells

Tag:

Human IgG1 Fc

Endotoxin Level:

Less than 0.01 EU/µg protein (determined by LAL method).

Molecular Weight:

~54kDa (SDS-PAGE)

Price:

50 µg/$386

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Human CD40 Protein (Recombinant Human IgG1 Fc) (aa21-193) - LS-G4046

Source:

CHO Cells

Tag:

Human IgG1 Fc

Biological Activity:

Biologically active

Endotoxin Level:

Less than 0.06 EU/µg protein (determined by LAL method).

Price:

100 µg/$519

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Mouse CD40 Protein (Recombinant His) (aa26-193) - LS-G24255

Source:

E. coli

Tag:

His

Molecular Weight:

22.5 kDa

Price:

10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176

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Rat CD40 Protein (Recombinant His-T7) (aa24-193) - LS-G24256

Source:

E. coli

Tag:

His-T7

Molecular Weight:

22.5 kDa

Price:

10 µg/$284; 50 µg/$460; 100 µg/$735; 200 µg/$917; 1 mg/$2,037; 500 µg/$1,571; 5 mg/$3,207; 2 mg/$2,225

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Human CD40 Protein (Recombinant GST) (Full Length) - LS-G27820

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

42.35 kDa

Price:

10 µg/$479; 25 µg/$670

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