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Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States
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Customer Service: (800) 227-6666 / (650) 697-3600
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CD3D
CD3d molecule, delta (CD3-TCR complex)
CD3D is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. The encoded membrane protein represents the delta subunit of the CD3 complex, and along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells. Defects in this gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK). Two transcript variants encoding different isoforms have been found for this gene. Other variants may also exist, but the full-length natures of their transcripts has yet to be defined.
| Gene Name: | CD3d molecule, delta (CD3-TCR complex) |
| Synonyms: | CD3D, CD3 delta, CD3d antigen, T-cell receptor T3 delta chain, T3D, CD3 antigen, delta subunit, CD3-DELTA, OKT3, delta chain |
| Target Sequences: | NM_000732 NP_000723.1 P04234 |
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