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CD36

CD36 molecule (thrombospondin receptor)

Binds to collagen, thrombospondin, anionic phospholipids and oxidized low-density lipoprotein (oxLDL). May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Receptor for thombospondins, THBS1 AND THBS2, mediating their antiangiogenic effects. As a coreceptor for TLR4-TLR6 heterodimer, promotes inflammation in monocytes/macrophages. Upon ligand binding, such as oxLDL or amyloid-beta 42, rapidly induces the formation of a heterodimer of TLR4 and TLR6, which is internalized and triggers inflammatory response, leading to NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion.

Gene Name:	CD36 molecule (thrombospondin receptor)
Synonyms:	CD36, Cluster determinant 36, FAT, Fatty acid translocase, Glycoprotein IIIb, gp4, GPIIIB, GPIV, PAS-4 protein, PAS IV, PASIV, Platelet collagen receptor, Platelet glycoprotein IV, SCARB3, Thrombospondin receptor, BDPLT10, CD36 antigen, CHDS7, gp3B, PAS-4, Platelet glycoprotein 4
Target Sequences:	NM_000072 NP_000063.2 P16671

Publications (22)

Targeted disruption of the class B scavenger receptor CD36 protects against atherosclerotic lesion development in mice. Febbraio M, Podrez EA, Smith JD, Hajjar DP, Hazen SL, Hoff HF, Sharma K, Silverstein RL. The Journal of clinical investigation. 2000 105:1049-56. [PubMed:10772649] [PMC:PMC300837]

Cardiomyocyte-specific knockout and agonist of peroxisome proliferator-activated receptor-gamma both induce cardiac hypertrophy in mice. Duan SZ, Ivashchenko CY, Russell MW, Milstone DS, Mortensen RM. Circulation research. 2005 97:372-9. (IHC, WB; Mouse) [PubMed:16051889]

Selection of an antibody library identifies a pathway to induce immunity by targeting CD36 on steady-state CD8 alpha+ dendritic cells. Tagliani E, Guermonprez P, Seplveda J, Lpez-Bravo M, Ardavn C, Amigorena S, Benvenuti F, Burrone OR. Journal of immunology (Baltimore, Md. : 1950). 2008 180:3201-9. (WB; Mouse) [PubMed:18292544]

Xanthophylls are preferentially taken up compared with beta-carotene by retinal cells via a SRBI-dependent mechanism. During A, Doraiswamy S, Harrison EH. Journal of lipid research. 2008 49:1715-24. [PubMed:18424859] [PMC:PMC2444002]

IL-6 deficiency increases fatty acid transporters and intramuscular lipid content in red but not white skeletal muscle. Chabowski A, Zmijewska M, Gorski J, Bonen A, Kaminski K, Kozuch M, Winnicka MM. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 2008 105-17. (WB; Mouse) [PubMed:19258660]

Scavenger receptors are associated with cellular interactions of S100A12 in vitro and in vivo. Hoppmann S, Steinbach J, Pietzsch J. The international journal of biochemistry & cell biology. 2010 42:651-61. [PubMed:20025991]

A novel role for the dioxin receptor in fatty acid metabolism and hepatic steatosis. Lee JH, Wada T, Febbraio M, He J, Matsubara T, Lee MJ, Gonzalez FJ, Xie W. Gastroenterology. 2010 139:653-63. [PubMed:20303349] [PMC:PMC2910786]

Oxidant production, oxLDL uptake, and CD36 levels in human monocytederived macrophages are downregulated by the macrophage-generated antioxidant 7,8-dihydroneopterin. Gieseg SP, Amit Z, Yang YT, Shchepetkina A, Katouah H. Antioxidants & redox signaling. 2010 13:1525-34. [PubMed:20408759]

Hyperinsulinemia and ectopic fat deposition can develop in the face of hyperadiponectinemia in young obese rats. Marecki JC, Ronis MJ, Shankar K, Badger TM. The Journal of nutritional biochemistry. 2011 22:142-52. [PubMed:20435456]

Modulation of macrophage fatty acid content and composition by exposure to dyslipidemic serum in vitro. Wong BX, Kyle RA, Croft KD, Quinn CM, Jessup W, Yeap BB. Lipids. 2011 46:371-80. [PubMed:21286835]

Abrogation of growth hormone secretion rescues fatty liver in mice with hepatocyte-specific deletion of JAK2. Sos BC, Harris C, Nordstrom SM, Tran JL, Balzs M, Caplazi P, Febbraio M, Applegate MA, Wagner KU, Weiss EJ. The Journal of clinical investigation. 2011 121:1412-23. (WB; Mouse) [PubMed:21364286] [PMC:PMC3069761]

Microglial cells contribute to endogenous brain defenses after acute neonatal focal stroke. Faustino JV, Wang X, Johnson CE, Klibanov A, Derugin N, Wendland MF, Vexler ZS. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2011 31:12992-3001. [PubMed:21900578] [PMC:PMC3539822]

CD9 tetraspanin interacts with CD36 on the surface of macrophages: a possible regulatory influence on uptake of oxidized low density lipoprotein. Huang W, Febbraio M, Silverstein RL. PloS one. 2011 6:e29092. [PubMed:22216174] [PMC:PMC3244426]

CD36 mediates proximal tubular binding and uptake of albumin and is upregulated in proteinuric nephropathies. Baines RJ, Chana RS, Hall M, Febbraio M, Kennedy D, Brunskill NJ. American journal of physiology. Renal physiology. 2012 303:F1006-14. (IHC, WB; Mouse) [PubMed:22791331]

Stored platelets alter glycerophospholipid and sphingolipid species, which are differentially transferred to newly released extracellular vesicles. Pienimaeki-Roemer A, Ruebsaamen K, Boettcher A, Ors E, Scherer M, Liebisch G, Kilalic D, Ahrens N, Schmitz G. Transfusion. 2013 53:612-26. (WB; Human) [PubMed:22804622]

C-Myc induced compensated cardiac hypertrophy increases free fatty acid utilization for the citric acid cycle. Olson AK, Ledee D, Iwamoto K, Kajimoto M, O'Kelly Priddy C, Isern N, Portman MA. Journal of molecular and cellular cardiology. 2013 55:156-64. (WB; Mouse) [PubMed:22828478] [PMC:PMC3524362]

Environment-mediated drug resistance in Bcr/Abl-positive acute lymphoblastic leukemia. Nair KS, Bigelow ML, Asmann YW, Chow LS, Coenen-Schimke JM, Klaus KA, Guo ZK, Sreekumar R, Irving BA. Oncoimmunology. 2012 1:618-629. (WB; Mouse) [PubMed:22934254] [PMC:PMC3429566]

Enhanced recovery from ischemia-reperfusion injury in PI3K dominant negative hearts: investigating the role of alternate PI3K isoforms, increased glucose oxidation and MAPK signaling. McLean BA, Kienesberger PC, Wang W, Masson G, Zhabyeyev P, Dyck JR, Oudit GY. Journal of molecular and cellular cardiology. 2013 54:18-Sep. (WB; Mouse) [PubMed:23142539]

Resistin-like molecule ß is abundantly expressed in foam cells and is involved in atherosclerosis development. Kushiyama A, Sakoda H, Oue N, Okubo M, Nakatsu Y, Ono H, Fukushima T, Kamata H, Nishimura F, Kikuchi T, Fujishiro M, Nishiyama K, Aburatani H, Kushiyama S, Iizuka M, Taki N, Encinas J, Sentani K, Ogonuki N, Ogura A, Kawazu S, Yasui W, Higashi Y, Kurihara H, Katagiri H, Asano T. Arteriosclerosis, thrombosis, and vascular biology. 2013 33:1986-93. (WB, IF; Mouse) [Full Text Article] [PubMed:23702657] Related Antibodies: LS-B662.

The mechanism of increased intestinal palmitic acid absorption and its impact on hepatic stellate cell activation in nonalcoholic steatohepatitis. Masakazu Hanayama, Yasunori Yamamoto, Hiroki Utsunomiya, Osamu Yoshida, Shuang Liu, Masaki Mogi, Bunzo Matsuura, Eiji Takeshita, Yoshiou Ikeda, Yoichi Hiasa. Scientific reports. 2021 June;11:13380. [Full Text Article] [PubMed:34183709] [PMC:PMC8239050] Related Antibodies: LS-B662.

Serum amyloid A induces mitogenic signals in regulatory T cells via monocyte activation. Khoa D Nguyen, Claudia Macaubas, Phi Truong, Nan Wang, Tieying Hou, Taejin Yoon, Elizabeth D Mellins. Molecular immunology. 2014 June;59:172-9. [Full Text Article] [PubMed:24632292] [PMC:PMC4068397]

Xanthine oxidoreductase is involved in macrophage foam cell formation and atherosclerosis development. Kushiyama A, Okubo H, Sakoda H, Kikuchi T, Fujishiro M, Sato H, Kushiyama S, Iwashita M, Nishimura F, Fukushima T, Nakatsu Y, Kamata H, Kawazu S, Higashi Y, Kurihara H, Asano T. Arteriosclerosis, thrombosis, and vascular biology. 2012 32:291-8. [PubMed:22095983] Related Antibodies: LS-B662.

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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