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CD27L / CD70
CD70 molecule
CD27L / CD70 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis.
| Gene Name: | CD70 molecule |
| Family/Subfamily: | TNF , not assigned-TNF |
| Synonyms: | CD70, CD27LG, Ki-24 antigen, Surface antigen CD70, CD27 ligand, CD27-L, CD70 antigen, CD70 molecule, TNFSF7 |
| Target Sequences: | NM_001252 NP_001243.1 P32970 |
Publications (3)
1
Mass Cytometry Analysis Reveals that Specific Intratumoral CD4+<sup> T Cell Subsets Correlate with Patient Survival in Follicular Lymphoma. Yang ZZ, Kim HJ, Villasboas JC, Price-Troska T, Jalali S, Wu H, Luchtel RA, Polley MC, Novak AJ, Ansell SM. Cell reports. 2019 February;26:2178-2193. [Full Text Article]
[PubMed:30784598]
[PMC:PMC6402596]
Related Antibodies: LS-A8809.
2
CD70 defines a subset of proinflammatory and CNS-pathogenic TH1/TH17 lymphocytes and is overexpressed in multiple sclerosis. Tessa Dhaeze, Laurence Tremblay, Catherine Lachance, Evelyn Peelen, Stephanie Zandee, Camille Grasmuck, Lyne Bourbonnière, Sandra Larouche, Xavier Ayrignac, Rose-Marie Rébillard, Josée Poirier, Boaz Lahav, Pierre Duquette, Marc Girard, Robert Moumdjian, Alain Bouthillier, Catherine Larochelle, Alexandre Prat. Cellular & molecular immunology. 2019 Jul;16:652-665. [Full Text Article]
[PubMed:30635649]
[PMC:PMC6804668]
3
CD70-specific CAR T cells have potent activity against acute myeloid leukemia without HSC toxicity. Tim Sauer, Kathan Parikh, Sandhya Sharma, Bilal Omer, David Sedloev, Qian Chen, Linus Angenendt, Christoph Schliemann, Michael Schmitt, Carsten Müller-Tidow, Stephen Gottschalk, Cliona M Rooney. Blood. 2021 July;138:318-330. [Full Text Article]
[PubMed:34323938]
[PMC:PMC8323977]
Related Antibodies: LS-A8809.
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ELISA Kits
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(4)
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CD27L / CD70
(9)
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Human
(3)
Mouse
(5)
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(1)
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96-Well Microplate
(3)
96-Well Strip Plate
(6)
Publications
No
(8)
Yes
(1)
Sample Type
Cell Culture Supernatants
(3)
Plasma
(5)
Serum
(5)
Tissue Homogenates
(1)
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$798
Sandwich
96-Well Microplate
Human
0.3 - 70 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$610
Custom
96-Well Microplate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$823
Sandwich
96-Well Microplate
Mouse
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$699
Sandwich
96-Well Strip Plate
Mouse
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$624
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$669
Custom
96-Well Strip Plate
Pig
Colorimetric - 450nm (TMB)
1 Plate/$669
Custom
96-Well Strip Plate
Mouse
10 - 100 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$897
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