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CD276 / B7-H3

CD276 molecule

May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling.

Gene Name: CD276 molecule
Synonyms: CD276, 4Ig-B7-H3, B7 homolog 3, B7-H3, CD276 antigen, CD276 molecule, Costimulatory molecule, B7H3, B7RP-2
Target Sequences: NM_025240 NP_079516.1 Q5ZPR3

Publications (3)

1
B7-H3 expression in colorectal cancer: associations with clinicopathological parameters and patient outcome. Ingebrigtsen VA, Boye K, Nesland JM, Nesbakken A, Flatmark K, Fodstad Ø. BMC cancer. 2014 14:602. (Flo; Human) [Full Text Article] [PubMed:25139714] [PMC:PMC4148536]
2
B7-H3 promotes the proliferation, migration and invasiveness of cervical cancer cells and is an indicator of poor prognosis. Li Y, Zhang J, Han S, Qian Q, Chen Q, Liu L, Zhang Y. Oncology reports. 2017 August;38:1043-1050. [Full Text Article] [PubMed:28627681]
3
Therapeutic HDAC inhibition in hypermutant diffuse intrinsic pontine glioma. Alyssa Noll, Carrie Myers, Matthew C Biery, Michael Meechan, Sophie Tahiri, Asmitha Rajendran, Michael E Berens, Danyelle Paine, Sara Byron, Jiaming Zhang, Conrad Winter, Fiona Pakiam, Sarah E S Leary, Bonnie L Cole, Evangeline R Jackson, Matthew D Dun, Jessica B Foster, Myron K Evans, Siobhan S Pattwell, James M Olson, Nicholas A Vitanza. Neoplasia (New York, N.Y.). 2023 September;43:100921. [Full Text Article] [PubMed:37603953] [PMC:PMC10565710] Related Antibodies: LS-C743430.

☰ Filters
Products
Proteins (28)
Over-Expression Lysate (6)
Recombinant (22)
CD276 / B7-H3 (28)
No (28)
6His, C-terminus (4)
DDK (Flag)-His, C-terminus (1)
Fc (1)
Fc, C-terminus (1)
His (1)
His, N-Terminal (1)
His,C-terminus (3)
His-T7 (2)
Human IgG1 Fc (1)
Mouse IgG2 Fc (2)
Mouse IgG2a Fc, N-terminus (1)
Myc-DDK (Flag) (7)
Crab-eating macaque (2)
Human (17)
Mouse (4)
Rat (2)
293T Cells (3)
CHO Cells (3)
E. coli (3)
HEK 293 Cells (11)
Human Cells (4)
Mammalian Cells (4)
Purified (7)
Low endotoxin level (17)
Biologically active (4)
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CHO Cells
Human IgG1 Fc
Less than 0.06 EU/µg protein (determined by LAL method).
100 µg/$463
Select
CHO Cells
Mouse IgG2 Fc
Biologically active
Less than 0.06 EU/µg protein (determined by LAL method).
100 µg/$463
Select
CHO Cells
Mouse IgG2 Fc
Less than 0.06 EU/µg protein (determined by LAL method).
100 µg/$463
Select
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
47.3kD
10 µg/$281; 50 µg/$420; 500 µg/$1,585; 1 mg/$2,157
Select
293T Cells
Myc-DDK (Flag)
57.1 kDa
20 µg/$150
Select
293T Cells
Myc-DDK (Flag)
57.1 kDa
20 µg/$215
CD276 / B7-H3 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
33.6 kDa
20 µg/$150
Select
Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
25 kDa
100 µg/$721
Select
Human Cells
Fc
Less than 1.0 EU/µg protein (determined by LAL method).
50.6 kDa
100 µg/$721
Select
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
24.3kD
10 µg/$266; 50 µg/$343; 500 µg/$1,377; 1 mg/$1,765
CD276 / B7-H3 Protein - Purified recombinant protein CD276 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
33.6 kDa
20 µg/$1,107
Select
HEK 293 Cells
Myc-DDK (Flag)
57.1 kDa
100 µg/$710
CD276 / B7-H3 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
33.6 kDa
100 µg/$494
Select
HEK 293 Cells
DDK (Flag)-His, C-terminus
49 kDa
20 µg/$1,107
Select
HEK 293 Cells
None
Less than 0.2 EU/µg protein (determined by LAL method).
62-65 kDa
100 µg/$444; 1 mg/$1,475
Select
HEK 293 Cells
None
Less than 0.2 EU/µg protein (determined by LAL method).
40-42 kDa
100 µg/$551; 1 mg/$1,717
Select
HEK 293 Cells
Myc-DDK (Flag)
57.1 kDa
100 µg/$494
Select
HEK 293 Cells
Mouse IgG2a Fc, N-terminus
Biologically active
Less than 5.0 EU/mg protein (determined by LAL method).
~100 kDa (SDS-PAGE)
100 µg/$466
Select
HEK 293 Cells
His,C-terminus
Biologically active
Less than 0.01 EU/µg protein (determined by LAL method).
~65 kDa (SDS-PAGE)
50 µg/$442
Select
HEK 293 Cells
None
Biologically active
Less than 0.01 EU/µg protein (determined by LAL method).
~35 kDa (SDS-PAGE)
50 µg/$442
Select
HEK 293 Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
48 kDa
100 µg/$721; 1 mg/$4,701
Select
Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
24.3 kDa
10 µg/$266; 50 µg/$339
Select
Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
47.3 kDa
10 µg/$281; 50 µg/$414
CD276 / B7-H3 Protein - Active Cluster Of Differentiation 276 (CD276) by WB
Select
E. coli
His, N-Terminal
22kDa
10 µg/$349; 50 µg/$865; 200 µg/$1,510; 100 µg/$1,284; 1 mg/$2,823; 500 µg/$2,318; 5 mg/$6,049; 2 mg/$3,227
Select
Mammalian Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
74 kDa
10 µg/$317; 50 µg/$524
Viewing 1-25 of 28 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).