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CD276 / B7-H3
CD276 molecule
May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling.
| Gene Name: | CD276 molecule |
| Synonyms: | CD276, 4Ig-B7-H3, B7 homolog 3, B7-H3, CD276 antigen, CD276 molecule, Costimulatory molecule, B7H3, B7RP-2 |
| Target Sequences: | NM_025240 NP_079516.1 Q5ZPR3 |
Publications (3)
1
B7-H3 expression in colorectal cancer: associations with clinicopathological parameters and patient outcome. Ingebrigtsen VA, Boye K, Nesland JM, Nesbakken A, Flatmark K, Fodstad Ø. BMC cancer. 2014 14:602. (Flo; Human)
[Full Text Article]
[PubMed:25139714]
[PMC:PMC4148536]
2
B7-H3 promotes the proliferation, migration and invasiveness of cervical cancer cells and is an indicator of poor prognosis. Li Y, Zhang J, Han S, Qian Q, Chen Q, Liu L, Zhang Y. Oncology reports. 2017 August;38:1043-1050. [Full Text Article]
[PubMed:28627681]
3
Therapeutic HDAC inhibition in hypermutant diffuse intrinsic pontine glioma. Alyssa Noll, Carrie Myers, Matthew C Biery, Michael Meechan, Sophie Tahiri, Asmitha Rajendran, Michael E Berens, Danyelle Paine, Sara Byron, Jiaming Zhang, Conrad Winter, Fiona Pakiam, Sarah E S Leary, Bonnie L Cole, Evangeline R Jackson, Matthew D Dun, Jessica B Foster, Myron K Evans, Siobhan S Pattwell, James M Olson, Nicholas A Vitanza. Neoplasia (New York, N.Y.). 2023 September;43:100921. [Full Text Article]
[PubMed:37603953]
[PMC:PMC10565710]
Related Antibodies: LS-C743430.
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(4)
CD276 / B7-H3 Rabbit anti-Human Polyclonal (aa493-522) Antibody
Human
Flo, IF, IHC-P, WB
Unconjugated
200 µl/$460
CD276 / B7-H3 Mouse anti-Human Monoclonal (6A1) Antibody
Human
ELISA, Flo, IHC, IHC-P, WB
Unconjugated
100 µl/$435
CD276 / B7-H3 Rabbit anti-Human Recombinant Monoclonal (RBT-B7H3) Antibody
Human
IHC-Fr, IHC-P
Unconjugated
0.1 ml/$502; 0.5 ml/$1,947; 1 ml/$2,856
CD276 / B7-H3 Rabbit anti-Human Recombinant Monoclonal (Ready-to-Use) (RBT-B7H3) Antibody
Human
IHC-Fr, IHC-P
Unconjugated, Ready-to-Use
3 ml/$502; 7 ml/$818; 15 ml/$1,299
CD276 / B7-H3 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
0.1 mg/$460
Sandwich
96-Well Strip Plate
Human
0.78 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$585
Sandwich
96-Well Strip Plate
Mouse
0.78 - 50 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$669
Sandwich
96-Well Microplate
Human
0.781 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
Cancer
CD276 / B7-H3 Rabbit anti-Human Polyclonal (aa47-219) Antibody
Human
ICC, IHC-P, IP, WB
Unconjugated
50 µl/$460
CD276 / B7-H3 Rat anti-Mouse Monoclonal (PE) (M3.2D7) Antibody
Mouse
Flo
PE Conjugated
25 µg/$307; 100 µg/$427
CD276 / B7-H3 Mouse anti-Human Monoclonal (8C1C2) Antibody
Human
ELISA, Flo, ICC, IHC, WB
Unconjugated
100 µl/$459
CD276 / B7-H3 Rabbit anti-Mouse Monoclonal (Preservative Free) (317) Antibody
Mouse
ELISA
Unconjugated, Preservative Free
100 µl/$412
CD276 / B7-H3 Rabbit anti-Human Polyclonal (aa47-219) (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$308; 200 µl/$350; 500 µl/$489; 1 ml/$558; 2 ml/$749; 5 ml/$1,217
Sandwich
96-Well Strip Plate
Human
0.781 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
CD276 / B7-H3 Mouse anti-Human Monoclonal (2H5) Antibody
Human
ELISA, Flo, ICC, IF, IHC-P, WB
Unconjugated
0.1 mg/$502
CD276 / B7-H3 Mouse anti-Human Monoclonal (2A7) Antibody
Human
ELISA, Flo, ICC, IF, IHC-P, WB
Unconjugated
0.1 mg/$502
CD276 / B7-H3 Mouse anti-Human Monoclonal (4H3) Antibody
Human
ELISA, Flo, ICC, IF, IHC-P, WB
Unconjugated
0.1 mg/$502
CD276 / B7-H3 Rabbit anti-Human Polyclonal (aa484-534) Antibody
Human
IHC, IP
Unconjugated
10 µg/$295; 100 µl/$514
CD276 / B7-H3 Mouse anti-Human Monoclonal (7B3) Antibody
Human
ELISA, Flo, ICC, IF, IHC-P
Unconjugated
0.1 mg/$502
CD276 / B7-H3 Mouse anti-Human Monoclonal (10G6) Antibody
Human
ELISA, Flo, ICC, IF, IHC-P
Unconjugated
0.1 mg/$502
CD276 / B7-H3 Rabbit anti-Mouse Polyclonal (aa47-213) Antibody
Mouse, Human
WB
Unconjugated
100 µl/$301; 200 µl/$340; 500 µl/$470; 1 ml/$535; 2 ml/$698; 5 ml/$1,161
CD276 / B7-H3 Mouse anti-Human Monoclonal Antibody
Human
ELISA, Flo, ICC, IF
Unconjugated
20 µl/$256; 100 µl/$412
CD276 / B7-H3 Mouse anti-Human Monoclonal Antibody
Human
ELISA, Flo, IHC, WB
Unconjugated
50 µg/$332; 100 µg/$404; 200 µg/$505
CD276 / B7-H3 Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Rat, Human
WB
Unconjugated
30 µl/$255; 100 µl/$299; 200 µl/$351
CD276 / B7-H3 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, Flo, IHC, WB
Unconjugated
100 µg/$406
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