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CD19

CD19 molecule

Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.

Gene Name: CD19 molecule
Synonyms: CD19, B-lymphocyte antigen CD19, CD19 molecule, Differentiation antigen CD19, T-cell surface antigen Leu-12, B4, CD19 antigen, CVID3
Target Sequences: NM_001770 NP_001761.3 P15391

Publications (7)

1
Cytomegalovirus-infected human endothelial cells can stimulate allogeneic CD4+ memory T cells by releasing antigenic exosomes. Walker JD, Maier CL, Pober JS. Journal of immunology (Baltimore, Md. : 1950). 2009 182:1548-59. [PubMed:19155503] [PMC:PMC2630120] Related Antibodies: LS-C40960.
2
Mouse mesenchymal stem cells can support human hematopoiesis both in vitro and in vivo: the crucial role of neural cell adhesion molecule. Wang X, Hisha H, Mizokami T, Cui W, Cui Y, Shi A, Song C, Okazaki S, Li Q, Feng W, Kato J, Ikehara S. Haematologica. 2010 95:884-91. [PubMed:20015889] [PMC:PMC2878784] Related Antibodies: LS-C40960.
3
Inhibition of in vivo HIV infection in humanized mice by gene therapy of human hematopoietic stem cells with a lentiviral vector encoding a broadly neutralizing anti-HIV antibody. Joseph A, Zheng JH, Chen K, Dutta M, Chen C, Stiegler G, Kunert R, Follenzi A, Goldstein H. Journal of virology. 2010 84:6645-53. [PubMed:20410262] [PMC:PMC2903239] Related Antibodies: LS-C40960.
4
Whole-transcriptome analysis of flow-sorted cervical cancer samples reveals that B cell expressed TCL1A is correlated with improved survival. Punt S, Corver WE, van der Zeeuw SA, Kielbasa SM, Osse EM, Buermans HP, de Kroon CD, Jordanova ES, Gorter A. Oncotarget. 2015 6:38681-94. (WB; Human) [Full Text Article] [PubMed:26299617] [PMC:PMC4770729] Related Antibodies: LS-C174739.
5
Deletion of Wiskott-Aldrich syndrome protein triggers Rac2 activity and increased cross-presentation by dendritic cells. Baptista MA, Keszei M, Oliveira M, Sunahara KK, Andersson J, Dahlberg CI, Worth AJ, Liedén A, Kuo IC, Wallin RP, Snapper SB, Eidsmo L, Scheynius A, Karlsson MC, Bouma G, Burns SO, Forsell MN, Thrasher AJ, Nylén S, Westerberg LS. Nature communications. 2016 7:12175. (Flo; Mouse) [Full Text Article] [PubMed:27425374] [PMC:PMC4960314]
6
The Neuroregenerative Capacity of Olfactory Stem Cells Is Not Limitless: Implications for Aging. Child KM, Herrick DB, Schwob JE, Holbrook EH, Jang W. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2018 August;38:6806-6824. [Full Text Article] [PubMed:29934351] [PMC:PMC6070664] Related Antibodies: LS-C122956.
7
Induction of resistance to chimeric antigen receptor T cell therapy by transduction of a single leukemic B cell. Marco Ruella, Jun Xu, David M Barrett, Joseph A Fraietta, Tyler J Reich, David E Ambrose, Michael Klichinsky, Olga Shestova, Prachi R Patel, Irina Kulikovskaya, Farzana Nazimuddin, Vijay G Bhoj, Elena J Orlando, Terry J Fry, Hans Bitter, Shannon L Maude, Bruce L Levine, Christopher L Nobles, Frederic D Bushman, Regina M Young, John Scholler, Saar I Gill, Carl H June, Stephan A Grupp, Simon F Lacey, J Joseph Melenhorst. Nature medicine. 2018 Oct;24:1499-1503. [Full Text Article] [PubMed:30275568] [PMC:PMC6511988] Related Antibodies: LS-C134319.
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Proteins (20)
Over-Expression Lysate (2)
Recombinant (18)
CD19 (20)
Bind (1)
ELISA (1)
Func (1)
SDS-PAGE (1)
No (20)
6His, C-terminus (1)
6His, N-terminus (1)
DDK (Flag)-His, C-terminus (1)
Fc, C-terminus (5)
GST (1)
GST, N-terminus (2)
His,C-terminus (3)
His-GST (1)
His-T7 (1)
Myc-DDK (Flag) (3)
Human (15)
Monkey-Rhesus (1)
Mouse (2)
Rat (1)
293T Cells (1)
CHO Cells (1)
E. coli (5)
HEK 293 Cells (7)
Human Cells (1)
Mammalian Cells (3)
Wheat Germ Extract (2)
Purified (8)
Low endotoxin level (8)
Biologically active (2)
CD19 Protein - Measured by its binding ability in a functional ELISA. Immobilized human CD19at 0.02µg/ml(100µL/well) can bind anti-human CD19 Mab with a linear range of 0.9-500 ng/ml.
Select
HEK 293 Cells
His,C-terminus
Bind ELISA Func SDS-PAGE
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
The recombinant human CD19 consists of 283 amino acids and predictes a molecular mass of 31.6 kDa. In SDS-PAGE under reducing conditions, rhCD19 migrates as an approximately 47 kDa band due to glycosylation.
50 µg/$480; 500 µg/$2,324
CD19 Protein - Recombinant Cluster Of Differentiation 19 By SDS-PAGE
Select
E. coli
His-T7
33.3 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
Select
HEK 293 Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
31 kDa
50 µg/$977
Select
Human Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
57.3kD
10 µg/$288; 50 µg/$442; 500 µg/$1,585; 1 mg/$2,157
CD19 Protein - 12.5% SDS-PAGE of human CD19 stained with Coomassie Blue
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Wheat Germ Extract
GST
87.5 kDa
10 µg/$479; 25 µg/$670
CD19 Protein - Recombinant Cluster Of Differentiation 19 By SDS-PAGE
Select
E. coli
GST, N-terminus
43.2 kDa
10 µg/$284; 50 µg/$462; 100 µg/$737; 200 µg/$922; 1 mg/$2,042; 500 µg/$1,577; 5 mg/$3,221; 2 mg/$2,231
CD19 Protein - Purified recombinant protein CD19 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
60.9 kDa
20 µg/$1,107
CD19 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
CD19 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
60.9 kDa
100 µg/$494
CD19 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
60.9 kDa
20 µg/$150
CD19 Protein
Select
HEK 293 Cells
Fc, C-terminus
57 kDa
20 µg/$1,107
CD19 Protein
Select
HEK 293 Cells
DDK (Flag)-His, C-terminus
32 kDa
20 µg/$1,107
Select
CHO Cells
None
Less than 0.2 EU/µg protein (determined by LAL method).
62 kDa
1 mg/$1,717; 50 µg/$444
CD19 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
Mammalian Cells
Fc, C-terminus
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
57.3 kDa
50 µg/$516; 10 µg/$313; 1 mg/$2,837; 500 µg/$1,987
Select
Mammalian Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
57.3 kDa
10 µg/$288; 50 µg/$436
Select
Mammalian Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
57.2 kDa
10 µg/$317; 50 µg/$524
CD19 Protein - Recombinant  Cluster Of Differentiation 19 By SDS-PAGE
Select
E. coli
His-GST
59.7 kDa
10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284
CD19 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
6His, N-terminus
100 µg/$1,299; 20 µg/$864
CD19 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
6His, C-terminus
100 µg/$1,128; 20 µg/$721
Select
HEK 293 Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
31.6 kDa
50 µg/$843; 500 µg/$4,903
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).