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CD177

CD177 molecule

CD177 encodes a glycosyl-phosphatidylinositol (GPI)-linked cell surface glycoprotein that plays a role in neutrophil activation. The protein can bind platelet endothelial cell adhesion molecule-1 and function in neutrophil transmigration. Mutations in this gene are associated with myeloproliferative diseases. Over-expression of this gene has been found in patients with polycythemia rubra vera. Autoantibodies against the protein may result in pulmonary transfusion reactions, and it may be involved in Wegener's granulomatosis. A related pseudogene, which is adjacent to this gene on chromosome 19, has been identified.

Gene Name: CD177 molecule
Synonyms: CD177, CD177 molecule, CD177 antigen, Cell surface receptor, HNA-2a, HNA2A, NB1, PRV-1, Polycythemia rubra vera 1, PRV1, NB1 glycoprotein, NB1 GP
Target Sequences: NM_020406 NP_065139.2 Q8N6Q3

Publications (2)

1
CXCL1-LCN2 paracrine axis promotes progression of prostate cancer via the Src activation and epithelial-mesenchymal transition. Lu Y, Dong B, Xu F, Xu Y, Pan J, Song J, Zhang J, Huang Y, Xue W. Cell Communication and Signaling. 2019 September;17:118. [Full Text Article] [PubMed:31500632] [PMC:PMC6734451] Related Antibodies: LS-B1953.
2
Expression of neuropeptides and cytokines in a rabbit model of diabetic neuroischemic wound healing. Pradhan Nabzdyk L, Kuchibhotla S, Guthrie P, Chun M, Auster ME, Nabzdyk C, Deso S, Andersen N, Gnardellis C, LoGerfo FW, Veves A. Journal of vascular surgery. 2013 Sep;58:766-75.e12. [Full Text Article] [PubMed:23755976] [PMC:PMC3755034] Related Antibodies: LS-B1953.

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Products
Proteins (9)
Over-Expression Lysate (2)
Recombinant (7)
CD177 (9)
No (9)
6His, C-terminus (2)
GST (1)
GST, N-terminus (1)
His-T7 (2)
Myc-DDK (Flag) (3)
Human (7)
Mouse (1)
293T Cells (1)
E. coli (2)
HEK 293 Cells (2)
Human Cells (1)
Mammalian Cells (1)
Wheat Germ Extract (2)
Purified (1)
Low endotoxin level (2)
CD177 Protein - Recombinant Neutrophil Specific Antigen 1 By SDS-PAGE
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E. coli
His-T7
33.7 kDa
10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
CD177 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
CD177 Protein - Purified recombinant protein CD177 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
46.2 kDa
20 µg/$1,107
CD177 Protein - Recombinant Neutrophil Specific Antigen 1 By SDS-PAGE
Select
E. coli
His-T7
21.8 kDa
50 µg/$452; 10 µg/$283; 200 µg/$902; 100 µg/$722; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
CD177 Protein - 12.5% SDS-PAGE of human CD177 stained with Coomassie Blue
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Wheat Germ Extract
GST
72.8 kDa
10 µg/$479; 25 µg/$670
CD177 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
46.2 kDa
20 µg/$150
CD177 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
46.2 kDa
100 µg/$494
Select
Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
42.3 kDa
10 µg/$288; 50 µg/$436
Select
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
42.33kD
10 µg/$288; 50 µg/$442; 500 µg/$1,585; 1 mg/$2,157
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).