CD163

CD163 molecule

Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells.After shedding, the soluble form (sCD163) may play an anti-inflammatory role, and may be a valuable diagnostic parameter for monitoring macrophage activation in inflammatory conditions.

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Products

Proteins (9)

Type

Over-Expression Lysate (2)

Recombinant (7)

Target

CD163 (9)

Publications

No (9)

Tag

6His, N-terminus (2)

GST, N-terminus (1)

His (3)

Myc-DDK (Flag) (3)

Species

Human (4)

Mouse (3)

Rat (1)

Source

293T Cells (1)

E. coli (4)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Yeast (1)

Low Endotoxin Level

Low endotoxin level (1)

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Rat CD163 Protein (Recombinant His) (aa693-939) - LS-G24444

Source:

E. coli

Tag:

His

Molecular Weight:

28.3 kDa

Price:

10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284

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Mouse CD163 Protein (Recombinant 6His, N-terminus) (aa697-972) - LS-G14212

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

34.0 kDa

Price:

10 µg/$292; 50 µg/$512; 100 µg/$817; 200 µg/$1,018; 1 mg/$2,168; 500 µg/$1,690; 5 mg/$3,571; 2 mg/$2,359

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Mouse CD163 Protein (Recombinant 6His, N-terminus) (aa86-365) - LS-G21713

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

34.3 kD

Price:

1 mg/$1,679; 100 µg/$500; 20 µg/$364

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Mouse CD163 Protein (Recombinant His) (aa86-365) - LS-G23402

Source:

Yeast

Tag:

His

Molecular Weight:

32.2 kD

Price:

100 µg/$499; 20 µg/$364; 1 mg/$1,683

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Human CD163 Protein (Recombinant GST, N-terminus) (aa78-168) - LS-G61073

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human CD163 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G69153

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

125.3 kDa

Price:

20 µg/$1,107

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CD163 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100247

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

125.3 kDa

Price:

100 µg/$494

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Human CD163 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G83940

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

125.3 kDa

Price:

20 µg/$150

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Human CD163 Protein (Recombinant His) (aa46-401) - LS-G141166

Source:

E. coli

Sequence Length:

355 AA

Tag:

His

Endotoxin Level:

Less than 0.1 EU/µg protein (determined by LAL method).

Molecular Weight:

39.16 kDa

Price:

10 mg/$4,268; 5 mg/$3,201; 1 mg/$1,868; 0.5 mg/$1,475; 200 µg/$1,103; 100 µg/$756; 50 µg/$531

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