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CD163

CD163 molecule

Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells.After shedding, the soluble form (sCD163) may play an anti-inflammatory role, and may be a valuable diagnostic parameter for monitoring macrophage activation in inflammatory conditions.

Gene Name: CD163 molecule
Synonyms: CD163, CD163 antigen, Macrophage-associated antigen, M130, CD163 molecule, Hemoglobin scavenger receptor, MM130
Target Sequences: NM_004244 NP_004235.4 Q86VB7

Publications (2)

1
Evaluation of immune cell markers in tumor tissue treated with radioimmunotherapy in an immunocompetent rat colon carcinoma model. Elgström E, Eriksson SE, Ljungberg O, Bendahl PO, Ohlsson TG, Nilsson R, Tennvall J. EJNMMI research. 2015 5:47. (IHC-P) [Full Text Article] [PubMed:26374556] [PMC:PMC4571030] Related Antibodies: LS-C96399.
2
Human galectin-9 promotes the expansion of HIV reservoirs in vivo in humanized mice. Zhe Yuan, Leila B Giron, Colin Hart, Akwasi Gyampoh, Jane Koshy, Kai Ying Hong, Toshiro Niki, Thomas A Premeaux, Lishomwa C Ndhlovu, Claire Deleage, Luis J Montaner, Mohamed Abdel-Mohsen. AIDS. 2023 March;37:571-577. [Full Text Article] [PubMed:36460646] [PMC:PMC9975043] Related Antibodies: LS-B2661.

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Products
ELISA Kits (26)
Custom (4)
Sandwich (20)
Sandwich CLIA (2)
CD163 (26)
Human (11)
Mouse (7)
Rat (2)
Dog (1)
Monkey (2)
Pig (2)
12 x 8-Well Microstrips (2)
96-Well Microplate (6)
96-Well Strip Plate (17)
No (26)
Cell Culture Supernatants (7)
Cell Lysates (2)
Heparin Plasma (1)
Plasma (21)
Serum (22)
Tissue Homogenates (7)
CD163 ELISA Kit
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Sandwich
96-Well Microplate
Mouse
0.78 - 50 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$699
CD163 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$715
CD163 ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$715
CD163 ELISA Kit
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Sandwich
96-Well Strip Plate
Monkey
0.781 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$587
CD163 ELISA Kit
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Sandwich
96-Well Strip Plate
Monkey
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$656
CD163 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$585
CD163 ELISA Kit
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Sandwich
96-Well Microplate
Mouse
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
CD163 ELISA Kit
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Sandwich
96-Well Strip Plate
Pig
93.75 - 6000 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$1,041
CD163 ELISA Kit
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Sandwich
96-Well Microplate
Human
32.77 - 3200 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$534
CD163 ELISA Kit
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Sandwich
12 x 8-Well Microstrips
Human
157 - 10000 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum
1 Plate/$534
CD163 ELISA Kit
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Sandwich
96-Well Microplate
Human
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$699
CD163 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
CD163 ELISA Kit
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Sandwich
Human
1.56 - 100 ng/ml
Cell Culture Supernatants, Heparin Plasma, Serum
1 Plate/$699
CD163 ELISA Kit
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Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$585
CD163 ELISA Kit
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Custom
96-Well Strip Plate
Dog
Colorimetric - 450nm (TMB)
1 Plate/$783
CD163 ELISA Kit
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Custom
96-Well Strip Plate
Colorimetric - 450nm (TMB)
1 Plate/$669
CD163 ELISA Kit
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Custom
96-Well Strip Plate
Pig
Colorimetric - 450nm (TMB)
1 Plate/$669
CD163 ELISA Kit
Select
Sandwich
96-Well Microplate
Human
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
CD163 ELISA Kit
Select
Sandwich
96-Well Microplate
Rat
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
CD163 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
1560 - 100000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$624
CD163 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
780 - 50000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$624
CD163 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$798
CD163 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
CD163 ELISA Kit
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Sandwich CLIA
96-Well Strip Plate
Human
40 - 2500 pg/ml
Chemiluminescent
Cell Lysates, Plasma, Serum
1 Plate/$562
CD163 ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Human
0.313 - 20 ng/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).