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CD151 is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. This protein enhances cell motility, invasion and metastasis of cancer cells. Multiple alternatively spliced transcript variants that encode the same protein have been described for this gene.
Gene Name: | CD151 molecule (Raph blood group) |
Family/Subfamily: | Tetraspan , not assigned-Tetraspan |
Synonyms: | CD151, CD151 antigen, gp27, Membrane glycoprotein SFA-1, PETA3, RAPH, SFA-1, TSPAN24, PETA-3, SFA1, MER2, Tetraspanin-24, Tspan-24 |
Target Sequences: | NM_004357 NP_004348.2 P48509 |
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