CD135 / FLT3

fms-related tyrosine kinase 3

Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways.

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Products

Proteins (12)

Type

Over-Expression Lysate (2)

Recombinant (10)

Target

CD135 / FLT3 (12)

Publications

No (12)

Tag

DDK (Flag)-His, C-terminus (1)

DDK,C-terminus (1)

Fc, C-terminus (1)

GST, N-terminus (1)

His (1)

His, C-terminus (1)

His-T7 (2)

Myc-DDK (Flag) (3)

Species

Human (9)

Mouse (2)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (3)

Human (1)

Human Cells (2)

Mammalian Cells (1)

Sf9 Cells (1)

Wheat Germ Extract (1)

Purification

Purified (1)

Low Endotoxin Level

Low endotoxin level (4)

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Human CD135 / FLT3 Protein (Recombinant Fc, C-terminus) (Asn27-Asn541) - LS-G138878

Source:

Mammalian Cells

Tag:

Fc, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

85.3 kDa

Price:

10 µg/$354; 50 µg/$425

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Human CD135 / FLT3 Protein (Recombinant His, C-terminus) (Met1-Asn541) - LS-G97482

Source:

Human Cells

Tag:

His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

59.7 kDa

Price:

100 µg/$926; 1 mg/$4,701

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Human CD135 / FLT3 Protein (Recombinant GST, N-terminus) (aa91-190) - LS-G58591

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human CD135 / FLT3 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65641

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

112.7 kDa

Price:

20 µg/$1,107

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Mouse CD135 / FLT3 Protein (Recombinant His-T7) (aa335-544) - LS-G23830

Source:

E. coli

Tag:

His-T7

Molecular Weight:

27.5 kDa

Price:

10 µg/$284; 50 µg/$460; 100 µg/$735; 200 µg/$917; 1 mg/$2,037; 500 µg/$1,571; 5 mg/$3,207; 2 mg/$2,225

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Human CD135 / FLT3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75947

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

112.7 kDa

Price:

20 µg/$215

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CD135 / FLT3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G116852

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

112.7 kDa

Price:

100 µg/$710

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Human CD135 / FLT3 Protein (Recombinant DDK (Flag)-His, C-terminus) - LS-G142198

Source:

HEK 293 Cells

Tag:

DDK (Flag)-His, C-terminus

Molecular Weight:

61.1 kDa

Price:

20 µg/$1,107

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Human CD135 / FLT3 Protein (Recombinant) - LS-G137920

Source:

Human

Tag:

None

Endotoxin Level:

Less than 0.1 ng/mL (Less than 1 EU/µg) (determined by LAL method).

Price:

10 µg/$266; 50 µg/$339; 500 µg/$1,010; 1 mg/$1,329

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Human CD135 / FLT3 Protein (Recombinant DDK,C-terminus) - LS-G142364

Source:

Sf9 Cells

Tag:

DDK,C-terminus

Molecular Weight:

58.3 kDa

Price:

20 µg/$677

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Mouse CD135 / FLT3 Protein (Recombinant His) (Met1-Ser544) - LS-G98154

Source:

Human Cells

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

59.5 kDa

Price:

50 µg/$483

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Human CD135 / FLT3 Protein (Recombinant His-T7) (aa334-543) - LS-G11348

Source:

E. coli

Tag:

His-T7

Molecular Weight:

26.9 kDa

Price:

10 µg/$282; 50 µg/$450; 100 µg/$717; 200 µg/$897; 1 mg/$2,010; 500 µg/$1,547; 5 mg/$3,137; 2 mg/$2,198

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