Corporate Headquarters
Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States
Plays a role as inhibitor of T-cells proliferation induced by CD3. Inhibits expression of IL2RA on activated T-cells and secretion of IL2. Inhibits tyrosine kinases that are required for IL2 production and cellular proliferation. Inhibits phospholipase C-gamma-1/PLCG1 phosphorylation and subsequent CD3-induced changes in intracellular free calcium. Prevents nuclear translocation of nuclear factor of activated T-cell to the nucleus. Plays a role in the inhibition of T-cell proliferation via IL10 secretion by cutaneous dendritic cells. May be a marker of CD4+ CD56+ leukemic tumor cells.
Gene Name: | CD101 molecule |
Family/Subfamily: | Immunoglobulin , not assigned-Immunoglobulin |
Synonyms: | CD101, CD101 antigen, CD101 molecule, Cell surface glycoprotein V7, EWI101, EWI-101, IGSF2, Leukocyte surface protein, V7 |
Target Sequences: | NM_004258 NP_004249.2 Q93033 |
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