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CCR5

chemokine (C-C motif) receptor 5 (gene/pseudogene)

CCR5 is a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. Two transcript variants encoding the same protein have been found for this gene.

Gene Name: chemokine (C-C motif) receptor 5 (gene/pseudogene)
Family/Subfamily: GPCR , Chemokine
Synonyms: CCR5, C-C chemokine receptor 5, CD195 antigen, CD195, C-C CKR-5, Chemokine c-c motif receptor 5, Chemr13, CMKBR5, CKR5, Cc chemokine receptor 5, CCCKR5, CCR-5, Ccr5 receptor, Chemokine receptor CCR5, HIV-1 fusion coreceptor, IDDM22, C-C chemokine receptor type 5, CC-CKR-5, CKR-5
Target Sequences: NM_000579 NP_000570.1 P51681

Publications (4)

1
Identification of a linear peptide recognized by monoclonal antibody 2D7 capable of generating CCR5-specific antibodies with human immunodeficiency virus-neutralizing activity. Khurana S, Kennedy M, King LR, Golding H. Journal of virology. 2005 79:6791-800. (Flo) [PubMed:15890918] [PMC:PMC1112162]
2
Gp120 V3-dependent impairment of R5 HIV-1 infectivity due to virion-incorporated CCR5. Monde K, Maeda Y, Tanaka Y, Harada S, Yusa K. The Journal of biological chemistry. 2007 282:36923-32. [PubMed:17971448] Related Antibodies: LS-C40887.
3
TLR2-dependent pathway of heterologous down-modulation for the CC chemokine receptors 1, 2, and 5 in human blood monocytes. Fox JM, Letellier E, Oliphant CJ, Signoret N. Blood. 2011 117:1851-60. [PubMed:21148810]
4
Chemokine receptor CXCR3 agonist prevents human T-cell migration in a humanized model of arthritic inflammation. O'Boyle G, Fox CR, Walden HR, Willet JD, Mavin ER, Hine DW, Palmer JM, Barker CE, Lamb CA, Ali S, Kirby JA. Proceedings of the National Academy of Sciences of the United States of America. 2012 109:4598-603. [PubMed:22392992] [PMC:PMC3311336]
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ELISA Kits (11)
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CCR5 (11)
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CCR5 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
CCR5 ELISA Kit
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Cell-Based Phosphorylation
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$668
CCR5 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$764
CCR5 ELISA Kit
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Cell-Based Phosphorylation
96-Well Microplate
Human
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$668
CCR5 ELISA Kit
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Cell-Based
96-Well Microplate
Human
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$534
CCR5 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
CCR5 ELISA Kit
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Custom
96-Well Strip Plate
Dog
Colorimetric - 450nm (TMB)
1 Plate/$783
CCR5 ELISA Kit
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Custom
96-Well Strip Plate
Colorimetric - 450nm (TMB)
1 Plate/$669
CCR5 ELISA Kit
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Custom
96-Well Strip Plate
Rat
Colorimetric - 450nm (TMB)
1 Plate/$669
CCR5 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
CCR5 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).