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CCR4
chemokine (C-C motif) receptor 4
High affinity receptor for the C-C type chemokines CCL17/TARC and CCL22/MDC. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival.
| Gene Name: | chemokine (C-C motif) receptor 4 |
| Family/Subfamily: | GPCR , Chemokine |
| Synonyms: | CCR4, C-C chemokine receptor type 4, CD194, CD194 antigen, C-C CKR-4, Chemr13, CKR-4, CC chemokine receptor 4, CC-CKR-4, CCR-4, HGCN:14099, C-c chemokine receptor 4, Chemokine (C-C) receptor 4, CKR4, CMKBR4, K5-5 |
| Target Sequences: | NM_005508 NP_005499.1 P51679 |
Publications (3)
1
Aberrant CCR4 expression is involved in tumor invasion of lymph node-negative human gastric cancer. Yang Y, Du L, Yang X, Qu A, Zhang X, Zhou C, Wang C. PloS one. 2015 10:e0120059. (IHC; Human)
[Full Text Article]
[PubMed:25790118]
[PMC:PMC4366399]
Related Antibodies: LS-A351.
2
CCR4 Expression Is Associated With Poor Prognosis in Patients With Early Stage (pN0) Oral Tongue Cancer. Lei Wang, Mei Zhang, Yuntao Zhu, Xin Zhang, Yongmei Yang, Chuanxin Wang. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons. 2019 Feb;77:426-432. [Full Text Article]
[PubMed:30395826]
Related Antibodies: LS-A351.
3
Aberrant expression of chemokine receptor CCR4 in human gastric cancer contributes to tumor-induced immunosuppression. Yang YM, Feng AL, Zhou CJ, Liang XH, Mao HT, Deng BP, Yan S, Sun JT, Du LT, Liu J, Wang QJ, Neckenig MR, Yang QF, Qu X. Cancer science. 2011 Jul;102:1264-71. [Full Text Article]
[PubMed:21443538]
Related Antibodies: LS-A351.
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96-Well Strip Plate
Mouse
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
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1 Plate/$669
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Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$764
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
Sandwich
96-Well Strip Plate
Human
78.125 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
Sandwich
96-Well Strip Plate
Human
78.125 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
Custom
96-Well Strip Plate
Dog
Colorimetric - 450nm (TMB)
1 Plate/$783
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