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Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
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CCR2

chemokine (C-C motif) receptor 2

CCR2, a Chemokine Receptor, is a regulator of monocyte/macrophage trafficking and is upregulated in response to inflammation. Resistance to HIV-1 infection or delayed progression to AIDS may be linked to CCR2 polymorphisms. The ligand for CCR2 is monocyte chemoattractant protein (MCP-1), a chemokine produced by endothelial cells, smooth muscle cells, and macrophages. Activation of monocytes by MCP-1 may mediate the monocytic infiltration of tissues in atherosclerosis (Boring et al., 1998) and other inflammatory disorders including rheumatoid arthritis, alveolitis, and tumor infiltration. Two isoforms are produced by alternative splicing.

Gene Name: chemokine (C-C motif) receptor 2
Family/Subfamily: GPCR , Chemokine
Synonyms: CCR2, C-C chemokine receptor type 2, CD192, Cc chemokine receptor 2, CCR-2, CCR2A, C-C CKR-2, CKR2, CD192 antigen, CKR2A, CKR2B, Mcp1 receptor, MCP-1 receptor, MCP-1-R, C-c chemokine receptor 2, CC-CKR-2, Cc-ckr2, CCR2B, CMKBR2, Mcp1r
Target Sequences: NP_001116868.1 P41597

Publications (1)

1
Interleukin-17 potently increases non-small cell lung cancer growth. Wei L, Wang H, Yang F, Ding Q, Zhao J. Molecular medicine reports. 2016 13:1673-80. (Flo; Mouse) [Full Text Article] [PubMed:26708832] Related Antibodies: LS-C127284.

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CCR2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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CCR2 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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10 µg/$479; 25 µg/$670
CCR2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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41.7 kDa
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40.9 kDa
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CCR2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
40.9 kDa
20 µg/$150
CCR2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
40.9 kDa
100 µg/$494
CCR2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
41.7 kDa
100 µg/$494
CCR2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
40.9 kDa
100 µg/$494
CCR2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
41.7 kDa
100 µg/$494
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).