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CCNH / Cyclin H
cyclin H
CCNH / Cyclin H belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK7 kinase and ring finger protein MAT1. The kinase complex is able to phosphorylate CDK2 and CDC2 kinases, thus functions as a CDK-activating kinase (CAK). This cyclin and its kinase partner are components of TFIIH, as well as RNA polymerase II protein complexes. They participate in two different transcriptional regulation processes, suggesting an important link between basal transcription control and the cell cycle machinery. A pseudogene of this gene is found on chromosome 4. Alternate splicing results in multiple transcript variants.
| Gene Name: | cyclin H |
| Synonyms: | CCNH, Cyclin H, p34, p37, CAK, CAK complex subunit, Cyclin-H, MO15-associated protein |
| Target Sequences: | NM_001239 NP_001230.1 P51946 |
Publications (3)
1
Cyclins B1, T1, and H differ in their molecular mode of interaction with cytomegalovirus protein kinase pUL97. Steingruber M, Keller L, Socher E, Ferre S, Hesse AM, Couté Y, Hahn F, Büscher N, Plachter B, Sticht H, Marschall M. The Journal of biological chemistry. 2019 April;294:6188-6203. [Full Text Article]
[PubMed:30782840]
[PMC:PMC6463711]
Related Antibodies: LS-C331195.
2
Functional Relevance of the Interaction between Human Cyclins and the Cytomegalovirus-Encoded CDK-Like Protein Kinase pUL97. Martin Schütz, Mirjam Steingruber, Eileen Socher , Regina Müller, Sabrina Wagner, Merle Kögel, Heinrich Sticht, Manfred Marschall. Viruses. 2021 Jun;13:1248. [Full Text Article]
[PubMed:34198986]
[PMC:PMC8310212]
Related Antibodies: LS-C331195.
3
Highly Conserved Interaction Profiles between Clinically Relevant Mutants of the Cytomegalovirus CDK-like Kinase pUL97 and Human Cyclins: Functional Significance of Cyclin H. Martin Schütz, Regina Müller, Eileen Socher, Christina Wangen, Florian Full, Emanuel Wyler, Diana Wong, Myriam Scherer, Thomas Stamminger, Sunwen Chou, William D Rawlinson, Stuart T Hamilton, Heinrich Sticht, Manfred Marschall. International journal of molecular sciences. 2022 October;23: [Full Text Article]
[PubMed:36233116]
[PMC:PMC9569496]
Related Antibodies: LS-C331195.
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CCNH / Cyclin H Rabbit anti-Human Polyclonal Antibody
Human
IF, IP, WB
Unconjugated
20 µl/$275; 100 µl/$389
CCNH / Cyclin H Mouse anti-Human Monoclonal (1B8) Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$460
CCNH / Cyclin H Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Rat, Pig, Human, Monkey
ICC, IF, IHC, IHC-P, WB
Unconjugated
30 µl/$255; 100 µl/$299; 200 µl/$351
CCNH / Cyclin H Rabbit anti-Human Polyclonal Antibody
Human
ELISA, Flo, IF, IHC, IP, WB
Unconjugated
100 µg/$331
CCNH / Cyclin H Rabbit anti-Human Polyclonal (aa262-311) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
100 µl/$515
CCNH / Cyclin H Rabbit anti-Human Polyclonal (p315) Antibody
Mouse, Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$357
CCNH / Cyclin H Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ICC, IF, IHC, WB
Unconjugated
50 µg/$305; 100 µg/$357
CCNH / Cyclin H Rabbit anti-Human Polyclonal (aa274-323) Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
CCNH / Cyclin H Rabbit anti-Human Polyclonal (pThr315) Antibody
Mouse, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
CCNH / Cyclin H Rabbit anti-Human Polyclonal (250-330 aa) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
CCNH / Cyclin H Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
CCNH / Cyclin H Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$294; 100 µg/$360
CCNH / Cyclin H Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, IHC, WB
Unconjugated
50 µg/$305; 100 µg/$357
CCNH / Cyclin H Rabbit anti-Human Polyclonal (pThr315) Antibody
Mouse, Human
IF, IHC, WB
Unconjugated
50 µg/$305; 100 µg/$357
CCNH / Cyclin H Rabbit anti-Human Polyclonal (Glu311) Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
50 µl/$321; 100 µl/$403
CCNH / Cyclin H Rabbit anti-Human Polyclonal (250-330 aa) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
CCNH / Cyclin H Rabbit anti-Human Polyclonal (aa269-299) Antibody
Human
ELISA, Flo, WB
Unconjugated
200 µl/$734
CCNH / Cyclin H Rabbit anti-Human Polyclonal (aa269-299) (Biotin) Antibody
Human
ELISA, Flo, WB
Biotin Conjugated
200 µl/$952
CCNH / Cyclin H Rabbit anti-Human Polyclonal (aa269-299) (FITC) Antibody
Human
ELISA, Flo, WB
FITC Conjugated
200 µl/$952
CCNH / Cyclin H Rabbit anti-Human Polyclonal (aa269-299) (APC) Antibody
Human
ELISA, Flo, WB
APC Conjugated
200 µl/$952
CCNH / Cyclin H Rabbit anti-Human Polyclonal (aa269-299) (PE) Antibody
Human
ELISA, Flo, WB
PE Conjugated
200 µl/$952
CCNH / Cyclin H Rabbit anti-Human Polyclonal (aa269-299) (Azide-free) (HRP) Antibody
Human
ELISA, Flo, WB
HRP Conjugated, Azide-free
200 µl/$952
CCNH / Cyclin H Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$397
CCNH / Cyclin H Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Rat, Pig, Human, Monkey
IHC, IHC-P, WB
Unconjugated
30 µl/$263; 100 µl/$315; 200 µl/$379
CCNH / Cyclin H Mouse anti-Human Monoclonal Antibody
Human
ELISA, WB
Unconjugated
150 µg/$842
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