CCND2 / Cyclin D2

cyclin D2

Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.

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Products

Proteins (12)

Type

Over-Expression Lysate (2)

Recombinant (10)

Target

CCND2 / Cyclin D2 (12)

Publications

No (12)

Tag

6His, N-terminus (3)

GST (1)

GST, N-terminus (2)

His (1)

His-T7 (2)

Myc-DDK (Flag) (3)

Species

Human (10)

Mouse (1)

Source

293T Cells (1)

E. coli (7)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (3)

Low Endotoxin Level

Low endotoxin level (2)

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Human CCND2 / Cyclin D2 Protein (Recombinant His) - LS-G1570

Source:

E. coli

Tag:

His

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

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Human CCND2 / Cyclin D2 Protein (Recombinant GST, N-terminus) (aa190-289) - LS-G58018

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human CCND2 / Cyclin D2 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65675

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

32.9 kDa

Price:

20 µg/$1,107

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Human CCND2 / Cyclin D2 Protein (Recombinant GST) (Full Length) - LS-G27775

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

59.5 kDa

Price:

10 µg/$479; 25 µg/$670

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Human CCND2 / Cyclin D2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G76011

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

32.9 kDa

Price:

20 µg/$150

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CCND2 / Cyclin D2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G118404

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

32.9 kDa

Price:

100 µg/$494

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Human CCND2 / Cyclin D2 Protein (Recombinant 6His, N-terminus) (Met1-Leu289) - LS-G139555

Source:

E. coli

Tag:

6His, N-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

35.4 kDa

Price:

10 µg/$376; 50 µg/$526

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Human CCND2 / Cyclin D2 Protein (Recombinant GST, N-terminus) (aa1-289) - LS-G56140

Source:

E. coli

Tag:

GST, N-terminus

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human CCND2 / Cyclin D2 Protein (Recombinant 6His, N-terminus) (Met1-Leu289) - LS-G39865

Source:

E. coli

Tag:

6His, N-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

35.36kD

Price:

10 µg/$288; 50 µg/$442; 500 µg/$1,585; 1 mg/$2,157

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Human CCND2 / Cyclin D2 Protein (Recombinant 6His, N-terminus) (Glu2-Leu289) - LS-G26534

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

35.2 kDa

Price:

10 µg/$265; 50 µg/$315; 100 µg/$365

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Human CCND2 / Cyclin D2 Protein (Recombinant His-T7) (aa68-278) - LS-G12422

Source:

E. coli

Tag:

His-T7

Molecular Weight:

27.5 kDa

Price:

10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148

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Mouse CCND2 / Cyclin D2 Protein (Recombinant His-T7) (aa47-267) - LS-G12423

Source:

E. coli

Tag:

His-T7

Molecular Weight:

28.9 kDa

Price:

10 µg/$287; 50 µg/$477; 100 µg/$762; 200 µg/$952; 1 mg/$2,083; 500 µg/$1,613; 5 mg/$3,333; 2 mg/$2,272

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