CCND1 / Cyclin D1

cyclin D1

Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner.

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Products

Proteins (12)

Type

Over-Expression Lysate (2)

Recombinant (10)

Target

CCND1 / Cyclin D1 (12)

Publications

No (12)

Tag

6His, N-terminus (1)

DDK,C-terminus (1)

GST (1)

His (3)

His, N-Terminal (1)

His-GST (1)

His-T7 (1)

Myc-DDK (Flag) (3)

Species

Bovine (1)

Chicken (1)

Human (7)

Mouse (1)

Rat (1)

Source

293T Cells (1)

E. coli (7)

HEK 293 Cells (2)

Sf9 Cells (1)

Wheat Germ Extract (1)

Purification

Purified (2)

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Human CCND1 / Cyclin D1 Protein (Recombinant 6His, N-terminus) (Full Length) - LS-G20572

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

37.8 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human CCND1 / Cyclin D1 Protein (Recombinant His-GST) (aa1-295) - LS-G12432

Source:

E. coli

Tag:

His-GST

Molecular Weight:

65.7 kDa

Price:

10 µg/$267; 50 µg/$352; 100 µg/$562; 200 µg/$702; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900

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Human CCND1 / Cyclin D1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65674

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

33.5 kDa

Price:

20 µg/$1,107

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Human CCND1 / Cyclin D1 Protein (Recombinant His, N-Terminal) (Glu2-Ile295) - LS-G96814

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

34 kDa

Price:

10 µg/$265; 100 µg/$365; 50 µg/$315

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CCND1 / Cyclin D1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G102168

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

33.5 kDa

Price:

100 µg/$494

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Human CCND1 / Cyclin D1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G76010

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

33.5 kDa

Price:

20 µg/$150

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Human CCND1 / Cyclin D1 Protein (Recombinant DDK,C-terminus) - LS-G142356

Source:

Sf9 Cells

Tag:

DDK,C-terminus

Molecular Weight:

34 kDa

Price:

20 µg/$677

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Human CCND1 / Cyclin D1 Protein (Recombinant GST) (Full Length) - LS-G27608

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

58.19 kDa

Price:

10 µg/$479; 25 µg/$670

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Mouse CCND1 / Cyclin D1 Protein (Recombinant His) (aa31-295) - LS-G12431

Source:

E. coli

Tag:

His

Molecular Weight:

29.1 kDa

Price:

10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284

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Bovine CCND1 / Cyclin D1 Protein (Recombinant His-T7) (aa72-272) - LS-G12433

Source:

E. coli

Tag:

His-T7

Molecular Weight:

26.3 kDa

Price:

10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204

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Chicken CCND1 / Cyclin D1 Protein (Recombinant His) (aa1-292) - LS-G12436

Source:

E. coli

Tag:

His

Molecular Weight:

34.8 kDa

Price:

10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119

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Rat CCND1 / Cyclin D1 Protein (Recombinant His) (aa1-295) - LS-G12438

Source:

E. coli

Tag:

His

Molecular Weight:

35.0 kDa

Price:

10 µg/$271; 50 µg/$382; 100 µg/$610; 200 µg/$762; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998

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