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Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions (By similarity). May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock.
Gene Name: | cerebral cavernous malformation 2 |
Synonyms: | CCM2, C7orf22, Malcavernin, PP10187 |
Target Sequences: | NM_031443 NP_113631.1 Q9BSQ5 |
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