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CCL8 / MCP2

chemokine (C-C motif) ligand 8

This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes, lymphocytes, basophils and eosinophils. By recruiting leukocytes to sites of inflammation this cytokine may contribute to tumor-associated leukocyte infiltration and to the antiviral state against HIV infection.

Gene Name: chemokine (C-C motif) ligand 8
Family/Subfamily: Intercrine , Intercrine beta
Synonyms: CCL8, C-C motif chemokine 8, HC14, MCP2, Monocyte chemotactic protein 2, Scya10, SCYA8, Small-inducible cytokine A8, MCP-2, Chemokine (C-C motif) ligand 8
Target Sequences: NM_005623 NP_005614.2 P80075

Publications (1)

1
Iron accelerates Fusobacterium nucleatum-induced CCL8 expression in macrophages and is associated with colorectal cancer progression. Taishi Yamane, Yohei Kanamori, Hiroshi Sawayama, Hiromu Yano, Akihiro Nita, Yudai Ohta, Hironori Hinokuma, Ayato Maeda, Akiko Iwai, Takashi Matsumoto, Mayuko Shimoda, Mayumi Niimura, Shingo Usuki, Noriko Yasuda-Yoshihara, Masato Niwa, Yoshifumi Baba, Takatsugu Ishimoto, Yoshihiro Komohara, Tomohiro Sawa, Tasuku Hirayama, Hideo Baba, Toshiro Moroishi. JCI insight. 2022 November;7: [Full Text Article] [PubMed:36136589] [PMC:PMC9675438] Related Antibodies: LS-B8198.

☰ Filters
Products
Proteins (27)
Over-Expression Lysate (2)
Recombinant (25)
CCL8 / MCP2 (27)
No (27)
6His, C-terminus (3)
6His, N-terminus (1)
DDK,C-terminus (1)
Fc (1)
GST (1)
His (2)
His, C-Terminal (1)
His-GST (2)
His-T7 (2)
Myc-DDK (Flag) (2)
Bovine (1)
Dog (1)
Human (16)
Mouse (7)
Pig (1)
293T Cells (1)
E. coli (17)
HEK 293 Cells (3)
Human Cells (2)
Mammalian Cells (2)
Yeast (2)
Purified (6)
Low endotoxin level (13)
Biologically active (9)
Animal-free (1)
Select
HEK 293 Cells
Fc
36.1 kDa
10 µg/$303; 50 µg/$462; 100 µg/$692
Select
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
8.9 kDa
2 µg/$268; 10 µg/$349
Select
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
8.5 kDa
5 µg/$268; 20 µg/$349
CCL8 / MCP2 Protein
Select
E. coli
None
Biologically active
8.9 kDa
10 µg/$388; 100 µg/$957; 500 µg/$1,747
CCL8 / MCP2 Protein
Select
E. coli
None
Biologically active
8.5 kDa
5 µg/$282; 100 µg/$957; 500 µg/$1,747
Select
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
8.9kD
10 µg/$321; 50 µg/$534; 500 µg/$1,585; 1 mg/$2,157
Select
Human Cells
His, C-Terminal
Less than 1.0 EU/µg protein (determined by LAL method).
9.8kD
10 µg/$321; 50 µg/$534; 500 µg/$1,680; 1 mg/$2,353
CCL8 / MCP2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
11.25 kDa
20 µg/$150
Select
Yeast
His
10.3 kDa
50 µg/$526
Select
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
9.95kD
10 µg/$281; 50 µg/$420; 500 µg/$1,585; 1 mg/$2,157
CCL8 / MCP2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
11.25 kDa
100 µg/$494
CCL8 / MCP2 Protein
Select
HEK 293 Cells
DDK,C-terminus
9.9 kDa
50 µg/$1,111
Select
E. coli
None
Biologically active
Less than 0.01 ng/µg of protein (Less than 0.1 EU/µg).
8.9 kDa
10 µg/$370; 2 µg/$282
Select
E. coli
None
Biologically active
Less than 0.01 ng/µg (determined by LAL method).
The 74 amino acid recombinant protein has a predicted molecular mass of approximately 8.48 kD. The DTT-reduced protein migrates at approximately 11 kDa and non-reduced protein migrates at approximately 12 kD by SDS-PAGE. The N-terminal amino acid is Gly.
10 µg/$352; 25 µg/$474; 100 µg/$731; 500 µg/$1,779
CCL8 / MCP2 Protein - THP-1 cells chemoattracted by human CCL8.
Select
E. coli
None
Biologically active
Less than 0.01 ng/µg (determined by LAL method).
The 76 amino acid recombinant protein has a predicted molecular mass of approximately 8.9 kD. The DTT-reduced protein migrates at approximately 11 kD and non-reduced protein migrates at approximately 12 kD by SDS-PAGE. The N-terminal amino acid is Gln.
10 µg/$352; 25 µg/$474
Select
Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
10.0 kDa
10 µg/$281; 50 µg/$414
CCL8 / MCP2 Protein - The ED(50) was determined by the dose-dependent proliferation of Jurkat cells and was found to be <0.05ng/mL.
Select
E. coli
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
~9 kDa
25 µg/$291; 250 µg/$1,021; 1 mg/$1,813
CCL8 / MCP2 Protein
Select
E. coli
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
~9 kDa
20 µg/$291; 200 µg/$1,021; 1 mg/$2,851
Select
Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
9.8 kDa
10 µg/$317; 50 µg/$524
Select
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
8.9 kDa
10 µg/$317; 50 µg/$524
CCL8 / MCP2 Protein - Recombinant Monocyte Chemotactic Protein 2 By SDS-PAGE
Select
E. coli
His-GST
38.6 kDa
10 µg/$289; 50 µg/$490; 100 µg/$782; 200 µg/$977; 1 mg/$2,114; 500 µg/$1,640; 5 mg/$3,417; 2 mg/$2,304
CCL8 / MCP2 Protein
Select
E. coli
6His, N-terminus
11.2 kDa
10 µg/$265; 50 µg/$315; 100 µg/$365
Select
E. coli
GST
36.3 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
Select
Yeast
His
10.9 kD
100 µg/$446; 20 µg/$336; 1 mg/$1,460
CCL8 / MCP2 Protein - Recombinant Monocyte Chemotactic Protein 2 By SDS-PAGE
Select
E. coli
His-GST
42.9 kDa
10 µg/$288; 50 µg/$487; 100 µg/$780; 200 µg/$972; 1 mg/$2,109; 500 µg/$1,636; 5 mg/$3,403; 2 mg/$2,298
Viewing 1-25 of 27 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).