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Shows chemotactic activity for lymphocytes and monocytes but not neutrophils. Also shows potent myelosuppressive activity, suppresses proliferation of myeloid progenitor cells. Recombinant SCYA16 shows chemotactic activity for monocytes and THP-1 monocytes, but not for resting lymphocytes and neutrophils. Induces a calcium flux in THP-1 cells that were desensitized by prior expression to RANTES.
Gene Name: | chemokine (C-C motif) ligand 16 |
Family/Subfamily: | Intercrine , Intercrine beta |
Synonyms: | CCL16, Cc chemokine lcc-1, CKb12, Chemokine hcc-4, Chemokine LEC, Chemokine lmc, ILINCK, Liver CC chemokine-1, Monotactin-1, NCC-4, LCC-1, LEC, Small-inducible cytokine A16, Liver-expressed chemokine, LMC, New CC chemokine 4, C-C motif chemokine 16, Chemokine CC-4, Chemokine ncc-4, HCC-4, IL-10-inducible chemokine, Mtn-1, NCC4, SCYA16, SCYL4 |
Target Sequences: | NM_004590 NP_004581.1 O15467 |
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