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CCDC88A / GIV / Girdin
coiled-coil domain containing 88A
Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. Enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB, but does not possess kinase activity itself. Phosphorylation of AKT1/PKB thereby induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation (By similarity). Essential for the integrity of the actin cytoskeleton and for cell migration. Required for formation of actin stress fibers and lamellipodia. May be involved in membrane sorting in the early endosome.
| Gene Name: | coiled-coil domain containing 88A |
| Synonyms: | CCDC88A, AKT-phosphorylation enhancer, APE, Akt phosphorylation enhancer, GIV, Girders of actin filament, Girdin, GRDN, Hook-related protein 1, KIAA1212, HkRP1 |
| Target Sequences: | NM_001135597 NP_001129069.1 Q3V6T2 |
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