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CCDC46 encodes a coiled-coil domain containing protein that belongs to the cell division control protein 42 effector protein family. In neurons, it localizes to the cytoplasm of dendrites and is also enriched in the nucleus where it interacts with the RNA polymerase III transcriptional repressor Maf1 to regulate gamma-aminobutyric acid A receptor surface expression. In addition, the protein has been identified as a component of the human centrosome. Alternative splicing results in multiple transcript variants.
Gene Name: | centrosomal protein 112kDa |
Synonyms: | CEP112, CCDC46, Centrosomal protein of 112 kDa, Centrosomal protein 112kDa, MACOCO |
Target Sequences: | W28100 Q8N8E3 Q8N8E3 |
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