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CCBL1

cysteine conjugate-beta lyase, cytoplasmic

Kidney cysteine conjugate beta-lyase (kyneurenine aminotranferase 1) metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites that can produce nephrotoxicity and neurotoxicity. KAT1 also catalyses the reversible transamination of glutamine to oxoglutaramic acid and converts kynurenine into kynurenic acid (KYNA), a broadspectrum antagonist at ionotropic excitatory amino acid receptors. It exists in a cytosolic and a mitochondrial form due to the presence of KAT1 mRNAs coding for proteins with and without leader sequences.

Gene Name: cysteine conjugate-beta lyase, cytoplasmic
Synonyms: CCBL1, Beta-lysase, kidney, KAT1, KATI, Kynurenine aminotransferase I, Kyneurenine aminotransferase, Kynurenic acid transferase 1, GTK, Glutamine transaminase K
Target Sequences: NM_004059 NP_004050.3 Q16773

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Proteins (11)
Over-Expression Lysate (4)
Recombinant (7)
CCBL1 (11)
No (11)
GST (2)
His (2)
His-SUMO (1)
Myc-DDK (Flag) (6)
Human (9)
293T Cells (2)
E. coli (3)
HEK 293 Cells (4)
Wheat Germ Extract (2)
Purified (3)
CCBL1 Protein - Recombinant Cysteine Conjugate Beta Lyase, Cytoplasmic By SDS-PAGE
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E. coli
His
51.6 kDa
10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148
CCBL1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
47.7 kDa
20 µg/$150
CCBL1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
47.7 kDa
20 µg/$215
CCBL1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
47.7 kDa
100 µg/$710
CCBL1 Protein - Purified recombinant protein KYAT1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
47.7 kDa
20 µg/$1,107
CCBL1 Protein - Purified recombinant protein KYAT1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
47.7 kDa
20 µg/$1,107
CCBL1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
47.7 kDa
100 µg/$494
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Wheat Germ Extract
GST
38.06 kDa
10 µg/$479; 25 µg/$670
CCBL1 Protein - 12.5% SDS-PAGE of human CCBL1 stained with Coomassie Blue
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Wheat Germ Extract
GST
66.88 kDa
10 µg/$479; 25 µg/$670
CCBL1 Protein
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E. coli
His-SUMO
58.5 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
CCBL1 Protein
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E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).