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Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
Gene Name: | chromobox homolog 8 |
Synonyms: | CBX8, Chromobox protein homolog 8, Pc class 3 homolog, Polycomb 3, RC1, PC3, Polycomb 3 homolog, Rectachrome 1, Chromobox homolog 8, HPC3 |
Target Sequences: | NM_020649 NP_065700.1 Q9HC52 |
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