CBLB

Cbl proto-oncogene B, E3 ubiquitin protein ligase

E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3.

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Products

Antibodies (17)

ELISA Kits (4)

Proteins (4)

Type

Custom (1)

Over-Expression Lysate (2)

Primary (17)

Recombinant (2)

Sandwich (3)

Target

CBLB (25)

Reactivity

Human (12)

Mouse (14)

Rat (3)

Application

IHC (5)

IHC-P (1)

WB (15)

DB (1)

ELISA (7)

IP (2)

Peptide-ELISA (1)

Host

rabbit (15)

mouse (2)

Product Group

IHCPlus (1)

Isotype

IgG (12)

IgG2a (2)

Clonality

monoclonal mc (2)

polyclonal pc (15)

Clone

246C5a (1)

Format

96-Well Strip Plate (4)

APC Conjugated (1)

Azide-free (1)

Biotin Conjugated (1)

FITC Conjugated (1)

HRP Conjugated (1)

PE Conjugated (1)

Unconjugated (12)

Epitope

aa862-889 (7)

aa450-500 (1)

aa932-982 (1)

Publications

No (25)

Sample Type

Cell Culture Supernatants (2)

Plasma (3)

Serum (3)

Tissue Homogenates (3)

Tag

GST (1)

Myc-DDK (Flag) (3)

Species

Human (3)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (1)

Select

CBLB Antibody LS-C77365

Antibody:

CBLB Mouse anti-Human Monoclonal Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

Unconjugated

Price:

50 µg/$558

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Mouse CBLB (Sandwich ELISA) ELISA Kit - LS-F19766

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

31.2 - 2000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$669

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Human CBLB (Sandwich ELISA) ELISA Kit - LS-F11039

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

78 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$669

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CBLB Antibody LS-C806305

Antibody:

CBLB Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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CBLB Antibody LS-C331824

Antibody:

CBLB Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 100 µl/$389

Select

CBLB Antibody (clone 246C5a) LS-C342566

Antibody:

CBLB Mouse anti-Human Monoclonal (246C5a) Antibody

Reactivity:

Mouse, Human

Applications:

DB, WB

Format:

Unconjugated

Price:

100 µg/$486

Select

CBLB Antibody (aa862-889) LS-C320019

Antibody:

CBLB Rabbit anti-Mouse Polyclonal (aa862-889) Antibody

Reactivity:

Mouse

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$734

Select

CBLB Antibody (aa862-889, Biotin) LS-C221663

Antibody:

CBLB Rabbit anti-Mouse Polyclonal (aa862-889) (Biotin) Antibody

Reactivity:

Mouse

Applications:

ELISA, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

Select

CBLB Antibody (aa862-889, FITC) LS-C221664

Antibody:

CBLB Rabbit anti-Mouse Polyclonal (aa862-889) (FITC) Antibody

Reactivity:

Mouse

Applications:

ELISA, WB

Format:

FITC Conjugated

Price:

200 µl/$952

Select

CBLB Antibody (aa862-889, APC) LS-C221662

Antibody:

CBLB Rabbit anti-Mouse Polyclonal (aa862-889) (APC) Antibody

Reactivity:

Mouse

Applications:

ELISA, WB

Format:

APC Conjugated

Price:

200 µl/$952

Select

CBLB Antibody (aa862-889, PE) LS-C221666

Antibody:

CBLB Rabbit anti-Mouse Polyclonal (aa862-889) (PE) Antibody

Reactivity:

Mouse

Applications:

ELISA, WB

Format:

PE Conjugated

Price:

200 µl/$952

Select

CBLB Antibody (aa862-889, Azide-free, HRP) LS-C221665

Antibody:

CBLB Rabbit anti-Mouse Polyclonal (aa862-889) (Azide-free) (HRP) Antibody

Reactivity:

Mouse

Applications:

ELISA, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• PE
• HRP, Azide-free

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • PE
  • HRP, Azide-free

Select

IHC-plus™ CBLB Antibody (aa450-500) LS-B13486

(4.0) Rating

Antibody:

CBLB Rabbit anti-Human Polyclonal (aa450-500) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, IP

Format:

Unconjugated

Price:

50 µl/$460

Select

Human CBLB Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81486

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

109.3 kDa

Price:

20 µg/$150

Select

CBLB Antibody LS-C341405

Antibody:

CBLB Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

50 µl/$356; 100 µl/$461

Select

CBLB Antibody LS-C765140

Antibody:

CBLB Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

60 µl/$331; 120 µl/$403; 200 µl/$529

Select

CBLB Antibody LS-C778659

Antibody:

CBLB Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µl/$357

Select

CBLB Antibody (aa932-982) LS-C289613

Antibody:

CBLB Rabbit anti-Human Polyclonal (aa932-982) Antibody

Reactivity:

Human

Applications:

IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

Select

CBLB Antibody (aa862-889) LS-C158182

Antibody:

CBLB Rabbit anti-Mouse Polyclonal (aa862-889) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Unconjugated

Price:

400 µl/$393

Select

CBLB Antibody LS-C659672

Antibody:

CBLB Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Format:

Unconjugated

Price:

100 µg/$331

Select

Rat CBLB (Custom ELISA) ELISA Kit - LS-F19767

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Rat

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$669

Select

Human CBLB Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G68121

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

109.3 kDa

Price:

20 µg/$1,107

Select

Human CBLB (Sandwich ELISA) ELISA Kit - LS-F33643

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

78 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

CBLB Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G102413

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

109.3 kDa

Price:

100 µg/$494

Select

Human CBLB Protein (Recombinant GST) (Full Length) - LS-G27761

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

135.8 kDa

Price:

10 µg/$479; 25 µg/$670

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