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May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression.
Gene Name: | caveolin 2 |
Synonyms: | CAV2, Caveolin 2 isoform a and b, Caveolin-2, CAV, Caveolae protein, 20-kD, Caveolin 2 |
Target Sequences: | NM_001233 NP_001224.1 P51636 |
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