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CAV1 / Caveolin 1

caveolin 1, caveolae protein, 22kDa

The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1.

Gene Name: caveolin 1, caveolae protein, 22kDa
Synonyms: CAV1, Caveolin-1, CGL3, CAV, MSTP085, VIP21, BSCL3
Target Sequences: NM_001753 NP_001744.2 Q03135

Publications (9)

1
Epithelial growth factor-induced phosphorylation of caveolin 1 at tyrosine 14 stimulates caveolae formation in epithelial cells. Orlichenko L, Huang B, Krueger E, McNiven MA. The Journal of biological chemistry. 2006 281:4570-9. [PubMed:16332692]
2
Akt regulates L-type Ca2+ channel activity by modulating Cavalpha1 protein stability. Catalucci D, Zhang DH, DeSantiago J, Aimond F, Barbara G, Chemin J, Bonci D, Picht E, Rusconi F, Dalton ND, Peterson KL, Richard S, Bers DM, Brown JH, Condorelli G. The Journal of cell biology. 2009 184:923-33. [PubMed:19307602] [PMC:PMC2699149]
3
Quantitative proteomics of caveolin-1-regulated proteins: characterization of polymerase i and transcript release factor/CAVIN-1 IN endothelial cells. Dvalos A, Fernndez-Hernando C, Sowa G, Derakhshan B, Lin MI, Lee JY, Zhao H, Luo R, Colangelo C, Sessa WC. Molecular & cellular proteomics : MCP. 2010 9:2109-24. [PubMed:20585024] [PMC:PMC2953909]
4
Functional heterogeneity of breast fibroblasts is defined by a prostaglandin secretory phenotype that promotes expansion of cancer-stem like cells. Rudnick JA, Arendt LM, Klebba I, Hinds JW, Iyer V, Gupta PB, Naber SP, Kuperwasser C. PloS one. 2011 6:e24605. [PubMed:21957456] [PMC:PMC3177828]
5
Matrix metalloproteinase-9 in homocysteine-induced intestinal microvascular endothelial paracellular and transcellular permeability. Munjal C, Tyagi N, Lominadze D, Tyagi SC. Journal of cellular biochemistry. 2012 113:1159-69. (ICC; Human) [PubMed:22275073] [PMC:PMC3337944]
6
AMP kinase activation improves angiogenesis in pulmonary artery endothelial cells with in utero pulmonary hypertension. Teng RJ, Du J, Afolayan AJ, Eis A, Shi Y, Konduri GG. American journal of physiology. Lung cellular and molecular physiology. 2013 304:L29-42. (WB; Sheep) [PubMed:23103561] [PMC:PMC3543642]
7
A Frame-Shift Mutation in CAV1 Is Associated with a Severe Neonatal Progeroid and Lipodystrophy Syndrome. Schrauwen I, Szelinger S, Siniard AL, Kurdoglu A, Corneveaux JJ, Malenica I, Richholt R, Van Camp G, De Both M, Swaminathan S, Turk M, Ramsey K, Craig DW, Narayanan V, Huentelman MJ. PloS one. 2015 10:e0131797. (WB; Human) [Full Text Article] [PubMed:26176221] [PMC:PMC4503302] Related Antibodies: LS-B192.
8
Ultrastructure and lipid composition of detergent-resistant membranes derived from mammalian sperm and two types of epithelial cells. van Gestel RA, Brouwers JF, Ultee A, Helms JB, Gadella BM. Cell and tissue research. 2016 363:129-45. (DB; Dog) [Full Text Article] [PubMed:26378009] [PMC:PMC4700079] Related Antibodies: LS-A2869.
9
Caveolin-1 selectively regulates microRNA sorting into microvesicles after noxious stimuli. Heedoo Lee, Chunhua Li, Yang Zhang, Duo Zhang, Leo E Otterbein, Yang Jin. The Journal of experimental medicine. 2019 September;216:2202-2220. [Full Text Article] [PubMed:31235510] [PMC:PMC6719430]
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Proteins (10)
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CAV1 / Caveolin 1 (10)
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GST (1)
His (3)
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293T Cells (2)
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CAV1 / Caveolin 1 Protein - 12.5% SDS-PAGE of human CAV1 stained with Coomassie Blue
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Wheat Germ Extract
GST
45.21 kDa
10 µg/$479; 25 µg/$670
CAV1 / Caveolin 1 Protein
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Yeast
His
22.6 kD
100 µg/$679; 20 µg/$429; 1 mg/$1,973
CAV1 / Caveolin 1 Protein - Recombinant Caveolin 1 By SDS-PAGE
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E. coli
His
13.5 kDa
10 µg/$307; 50 µg/$602; 100 µg/$962; 200 µg/$1,156; 1 mg/$2,369; 500 µg/$1,876; 5 mg/$4,201; 2 mg/$2,562
CAV1 / Caveolin 1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
20.3 kDa
100 µg/$494
CAV1 / Caveolin 1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
20.3 kDa
20 µg/$150
CAV1 / Caveolin 1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
20.47 kDa
20 µg/$150
CAV1 / Caveolin 1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
20.47 kDa
100 µg/$494
CAV1 / Caveolin 1 Protein - Recombinant Caveolin 1 By SDS-PAGE
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E. coli
His-GST
43.9 kDa
10 µg/$294; 50 µg/$522; 100 µg/$832; 200 µg/$1,034; 1 mg/$2,192; 500 µg/$1,712; 5 mg/$3,641; 2 mg/$2,383
CAV1 / Caveolin 1 Protein - Recombinant Caveolin 1 By SDS-PAGE
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E. coli
His
13.4 kDa
10 µg/$286; 50 µg/$472; 100 µg/$757; 200 µg/$945; 1 mg/$2,073; 500 µg/$1,604; 5 mg/$3,305; 2 mg/$2,262
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).