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Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH.
Gene Name: | cation channel, sperm associated 2 |
Family/Subfamily: | Ion Channel , Calcium channel - sperm associated |
Synonyms: | CATSPER2, Sperm ion channel |
Target Sequences: | NM_054020 NP_473361.1 Q96P56 |
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