CATSPER1 / CATSPER

cation channel, sperm associated 1

Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH.

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Products

Proteins (2)

Type

Recombinant (2)

Target

CATSPER1 / CATSPER (2)

Publications

No (2)

Tag

GST (1)

GST, N-terminus (1)

Species

Human (2)

Source

Wheat Germ Extract (2)

Purification

Purified (1)

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Human CATSPER1 / CATSPER Protein (Recombinant GST) (Full Length) - LS-G36275

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

116.5 kDa

Price:

2 µg/$439

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Human CATSPER1 / CATSPER Protein (Recombinant GST, N-terminus) (aa681-780) - LS-G63583

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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