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CASP9 / Caspase 9

caspase 9, apoptosis-related cysteine peptidase

CASP9 / Caspase 9 is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein can undergo autoproteolytic processing and activation by the apoptosome, a protein complex of cytochrome c and the apoptotic peptidase activating factor 1; this step is thought to be one of the earliest in the caspase activation cascade. This protein is thought to play a central role in apoptosis and to be a tumor suppressor. Alternative splicing results in multiple transcript variants.

Gene Name: caspase 9, apoptosis-related cysteine peptidase
Family/Subfamily: Protease , Cysteine C14
Synonyms: CASP9, APAF3, CASPASE-9c, ICE-LAP6, MCH6, ICE-like apoptotic protease 6, APAF-3, Apoptotic protease Mch-6, CASP-9, Caspase 9, Caspase-9, PPP1R56
Target Sequences: NM_001229 NP_001220.2 P55211

Publications (2)

1
Apocytochrome c blocks caspase-9 activation and Bax-induced apoptosis. Martin AG, Fearnhead HO. The Journal of biological chemistry. 2002 277:50834-41. [PubMed:12393884]
2
Caspase-9 acts as a regulator of necroptotic cell death10<sup> Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, Hungary. Tamás Molnár , Petra Pallagi , Bálint Tél , Róbert Király, Eszter Csoma, Viktória Jenei, Zsófia Varga , Péter Gogolák, Anne Odile Hueber, Zoltán Máté, Ferenc Erdélyi, Gábor Szabó, Aladár Pettkó-Szandtner, Attila Bácsi, László Virág, József Maléth , Gábor Koncz. The Breast : official journal of the European Society of Mastology. 2021 Nov;;288:6476-6491. [Full Text Article] [PubMed:33899329] Related Antibodies: LS-C148248.

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CASP9 / Caspase 9 Antibody - IHC of Caspase-9 expression in formalin-fixed, paraffin-embedded mouse brain tissue sections using Polyclonal Antibody to Caspase-9 at 1:2000. Hematoxylin-Eosin counterstain. A: Brain striatum. B: Brain stem motor neuron.
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CASP9 / Caspase 9 Antibody LS-C148248
(4.0) Rating
(1) Publication(s)
CASP9 / Caspase 9 Rabbit anti-Human Polyclonal Antibody
Mouse, Dog, Rat, Human
IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
50 µl/$386
CASP9 / Caspase 9 Antibody - Formalin-fixed, paraffin-embedded dog brain sections stained for cleaved Caspase-9 expression using Polyclonal Antibody to (Active) Cleaved Caspase-9 antibody at 1:2000. A and B. The pattern of Caspase-9 staining may vary between different types of neurons. Hematoxylin-Eosin counterstain.
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CASP9 / Caspase 9 Antibody LS-C148247
CASP9 / Caspase 9 Rabbit anti-Human Polyclonal Antibody
Mouse, Dog, Rat, Gerbil, Human
IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
50 µl/$386
CASP9 / Caspase 9 Antibody - Anti-Caspase 9 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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IHC-plus™ CASP9 / Caspase 9 Antibody (aa345-359) LS-B2021
(4.0) Rating
CASP9 / Caspase 9 Rabbit anti-Rat Polyclonal (aa345-359) Antibody
Rat, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$460
CASP9 / Caspase 9 Antibody - Immunohistochemical analysis of Caspase 9 staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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CASP9 / Caspase 9 Antibody (Internal) LS-C351940
CASP9 / Caspase 9 Rabbit anti-Human Polyclonal (Internal) Antibody
Human, Monkey
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$299
CASP9 / Caspase 9 Antibody - Anti-Caspase 9 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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IHC-plus™ CASP9 / Caspase 9 Antibody LS-B3741
(4.0) Rating
CASP9 / Caspase 9 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, ICC, IF, IHC, IHC-P, IP, WB
Unconjugated
0.05 mg/$460
CASP9 / Caspase 9 Antibody - Anti-Caspase 9 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.
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IHC-plus™ CASP9 / Caspase 9 Antibody (clone LAP6 96-2-22) LS-B241
(4.0) Rating
CASP9 / Caspase 9 Mouse anti-Human Monoclonal (LAP6 96-2-22) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
CASP9 / Caspase 9 Antibody - Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE)
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IHC-plus™ CASP9 / Caspase 9 Antibody (Cleaved Asp353) LS-B16842
(4.0) Rating
CASP9 / Caspase 9 Rabbit anti-Human Polyclonal (Cleaved Asp353) Antibody
Mouse, Rat, Human
ICC, IF, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
CASP9 / Caspase 9 ELISA Kit
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Human Phospho-CASP9 / Caspase 9 (Ser196) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1327
Cell-Based Phosphorylation
96-Well Microplate
Human
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$668
CASP9 / Caspase 9 Antibody - Immunohistochemical analysis of Caspase 9 p35 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP-conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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CASP9 / Caspase 9 Antibody (C-Terminus) LS-C358444
CASP9 / Caspase 9 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$299
CASP9 / Caspase 9 Antibody - Immunofluorescent analysis of Caspase 9 staining in HeLa cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 deg C in a humidified chamber. Cells were washed with PBST and incubated with a FITC-conjugated secondary antibody (green) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue).
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CASP9 / Caspase 9 Antibody LS-C413507
CASP9 / Caspase 9 Mouse anti-Human Monoclonal Antibody
Mouse, Rat, Human
ICC, IF, IP, WB
Unconjugated
100 µl/$321
CASP9 / Caspase 9 Antibody - Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using Caspase 9 Antibody. The picture on the right is blocked with the synthesized peptide.
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CASP9 / Caspase 9 Antibody (aa91-140) LS-C117554
CASP9 / Caspase 9 Rabbit anti-Human Polyclonal (aa91-140) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
CASP9 / Caspase 9 Antibody - Western blot of Cleaved-Caspase-9 p35 (D315) antibody
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CASP9 / Caspase 9 Antibody (240-320 aa, Internal) LS-C380460
CASP9 / Caspase 9 Rabbit anti-Human Polyclonal (240-320 aa, Internal) Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
CASP9 / Caspase 9 Antibody - Anti-Caspase 9 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 10 ug/ml.
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PathPlus™ CASP9 / Caspase 9 Antibody (aa266-315) LS-B7727
Neuroscience
(5.0) Rating
CASP9 / Caspase 9 Rabbit anti-Human Polyclonal (aa266-315) Antibody
Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$440
CASP9 / Caspase 9 Antibody - Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
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CASP9 / Caspase 9 Antibody (phospho-Ser196) LS-C97424
CASP9 / Caspase 9 Rabbit anti-Human Polyclonal (pSer196) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
CASP9 / Caspase 9 Antibody - Western blot analysis of lysates from 293 cells treated with Calyculin 50nM 30', using Caspase 9 (Phospho-Ser196) Antibody. The lane on the right is blocked with the phospho peptide.
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CASP9 / Caspase 9 Antibody (phospho-Ser196) LS-C198733
CASP9 / Caspase 9 Rabbit anti-Human Polyclonal (pSer196) Antibody
Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
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CASP9 / Caspase 9 Antibody LS-C12569
CASP9 / Caspase 9 Mouse anti-Human Monoclonal Antibody
Human
WB
Unconjugated
200 µg/$688
CASP9 / Caspase 9 Antibody - Immunohistochemical analysis of Caspase 9 p35 staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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CASP9 / Caspase 9 Antibody (Internal) LS-C413408
CASP9 / Caspase 9 Rabbit anti-Human Polyclonal (Internal) Antibody
Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$321
CASP9 / Caspase 9 Antibody - Immunohistochemical analysis of Caspase 9 staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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CASP9 / Caspase 9 Antibody (Internal) LS-C351948
CASP9 / Caspase 9 Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Rat, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$299
CASP9 / Caspase 9 Antibody - Immunohistochemical analysis of Caspase 9 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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CASP9 / Caspase 9 Antibody (Internal) LS-C353929
CASP9 / Caspase 9 Rabbit anti-Human Polyclonal (Internal) Antibody
Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$299
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CASP9 / Caspase 9 Antibody LS-C659588
CASP9 / Caspase 9 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, Flo, IF, IHC, IP, WB
Unconjugated
100 µg/$331
CASP9 / Caspase 9 Antibody - 1:100 staining rat spleen tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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CASP9 / Caspase 9 Antibody LS-C808664
CASP9 / Caspase 9 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
CASP9 / Caspase 9 Antibody - Peptide - + Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using Caspase 9 (Ab-125) antibody.
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CASP9 / Caspase 9 Antibody (p125) LS-C821694
CASP9 / Caspase 9 Rabbit anti-Human Polyclonal (p125) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$357
CASP9 / Caspase 9 Antibody - 1:100 staining human Testis tissue by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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CASP9 / Caspase 9 Antibody (phospho-Thr125) LS-C808530
CASP9 / Caspase 9 Rabbit anti-Human Polyclonal (pThr125) Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
CASP9 / Caspase 9 Antibody - Western blot of Caspase 9 expression in TNF-a treated NIH-3T3 whole cell lysates,The lane on the left is treated with the antigen-specific peptide.
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CASP9 / Caspase 9 Antibody LS-C417565
CASP9 / Caspase 9 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ICC, IF, IHC, WB
Unconjugated
50 µg/$305; 100 µg/$357
CASP9 / Caspase 9 Antibody - Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with CASP9 antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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CASP9 / Caspase 9 Antibody (aa183-211) LS-C99786
CASP9 / Caspase 9 Rabbit anti-Human Polyclonal (aa183-211) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
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