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Calpains are calcium-dependent cysteine proteases involved in signal transduction in a variety of cellular processes. A functional calpain protein consists of an invariant small subunit and 1 of a family of large subunits. CAPN5 is one of the large subunits. Unlike some of the calpains, CAPN5 and CAPN6 lack a calmodulin-like domain IV. Because of the significant similarity to Caenorhabditis elegans sex determination gene tra-3, CAPN5 is also called as HTRA3.
Gene Name: | calpain 5 |
Family/Subfamily: | Protease , Cysteine C2 |
Synonyms: | CAPN5, Calpain-5, Calpain htra-3, Calpain-like protease 3, Htra-3, NCL-3, Calpain 5, NCL3, New calpain 3 |
Target Sequences: | NM_004055 NP_004046.2 O15484 |
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