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CAPN2 / Calpain 2 / M-Calpain

calpain 2, (m/II) large subunit

The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 2. Multiple heterogeneous transcriptional start sites in the 5' UTR have been reported. Two transcript variants encoding different isoforms have been found for this gene.

Gene Name: calpain 2, (m/II) large subunit
Family/Subfamily: Protease , Cysteine C2
Synonyms: CAPN2, Calpain 2, large subunit, Calpain ii, Calpain, large polypeptide L2, Calpain-2 catalytic subunit, Calpain 2, Calpain large polypeptide L2, Calpain-2 large subunit, CANP 2, Calpain M-type, CANP2, CANPL2, CANPml, M-type calpain, M-calpain, MCANP, Millimolar-calpain
Target Sequences: NM_001748 NP_001739.2 P17655

Publications (2)

1
The tyrosine phosphatase PTPN13/FAP-1 links calpain-2, TBI and tau tyrosine phosphorylation. Wang Y, Hall RA, Lee M, Kamgar-Parsi A, Bi X, Baudry M. Scientific reports. 2017 7:11771. (WB; Human) [Full Text Article] [PubMed:28924170] [PMC:PMC5603515] Related Antibodies: LS-B12657.
2
Defects in the CAPN1 Gene Result in Alterations in Cerebellar Development and Cerebellar Ataxia in Mice and Humans. Wang Y, Hersheson J, Lopez D, Hammer M, Liu Y, Lee KH, Pinto V, Seinfeld J, Wiethoff S, Sun J, Amouri R, Hentati F, Baudry N, Tran J, Singleton AB, Coutelier M, Brice A, Stevanin G, Durr A, Bi X, Houlden H, Baudry M. Cell reports. 2016 16:79-91. (WB; Human) [Full Text Article] [PubMed:27320912] Related Antibodies: LS-B12657.

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Products
Proteins (7)
Over-Expression Lysate (2)
Recombinant (5)
CAPN2 / Calpain 2 / M-Calpain (7)
No (7)
6His, N-terminus (1)
GST (1)
His-SUMO (1)
His-T7 (1)
Myc-DDK (Flag) (3)
Human (5)
Pig (1)
293T Cells (1)
E. coli (3)
HEK 293 Cells (2)
Wheat Germ Extract (1)
Purified (2)
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E. coli
6His, N-terminus
82.2 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
CAPN2 / Calpain 2 / M-Calpain Protein - Recombinant  Calpain 2, Large Subunit By SDS-PAGE
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E. coli
His-T7
57.4 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
CAPN2 / Calpain 2 / M-Calpain Protein - 12.5% SDS-PAGE of human CAPN2 stained with Coomassie Blue
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Wheat Germ Extract
GST
106.4 kDa
10 µg/$479; 25 µg/$670
CAPN2 / Calpain 2 / M-Calpain Protein
Select
E. coli
His-SUMO
53.8 kD
1 mg/$1,679; 100 µg/$598; 20 µg/$405
CAPN2 / Calpain 2 / M-Calpain Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
79.8 kDa
100 µg/$494
CAPN2 / Calpain 2 / M-Calpain Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
79.8 kDa
20 µg/$150
CAPN2 / Calpain 2 / M-Calpain Protein - Purified recombinant protein CAPN2 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
79.8 kDa
20 µg/$1,107
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).